DegronMD - Q8IW00(VSTM4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E317K	TCGA-D3-A2J8	SKCM	TCGA	APTST	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.0833
p.E317K	TCGA-FS-A4F5	SKCM	TCGA	APTST	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.0833
p.E317K	DO227496	LAML	ICGC	APTST	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.0833
p.E317K	DO231101	LAML	ICGC	APTST	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.0833
p.E317K	DO37881	SKCM	ICGC	APTST	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.0833
p.E317K	DO37778	SKCM	ICGC	APTST	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.0833
p.L314I	TCGA-F1-6874	STAD	TCGA	APTST	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.1667
p.L314I	DO38201	STAD	ICGC	APTST	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.1667
p.P305H	TCGA-FS-A1ZY	SKCM	TCGA	APTST	DEG_SPOP_SBC_1	304:308	Mutation altering degron motif	0.6583
p.P305H	DO38135	SKCM	ICGC	APTST	DEG_SPOP_SBC_1	304:308	Mutation altering degron motif	0.6583
p.E316K	TCGA-HQ-A2OE	BLCA	TCGA	APTST	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.1111
p.E316K	DO540	BLCA	ICGC	APTST	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.1111
p.A304T	TCGA-ZG-A9LZ	PRAD	TCGA	APTST	DEG_SPOP_SBC_1	304:308	Mutation altering degron motif	0.7139
p.A304T	DO227820	BRCA	ICGC	APTST	DEG_SPOP_SBC_1	304:308	Mutation altering degron motif	0.7139
p.A304T	DO219440	PRAD	ICGC	APTST	DEG_SPOP_SBC_1	304:308	Mutation altering degron motif	0.7139
p.H298L	DO232026	LICA	ICGC	APTST	DEG_SPOP_SBC_1	304:308	Mutation rewiring degron network	0.1667
p.T308A	ACH-001991	Primary	CCLE	APTST	DEG_SPOP_SBC_1	304:308	Mutation altering degron motif	0.7139

Kaplan plot for VSTM4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VSTM4

UniProt ID: Q8IW00

Entrez ID: 196740

Protein name: V-set and transmembrane domain-containing protein 4 [Cleaved into: Peptide Lv]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VSTM4 in