DegronMD

Uniprot ID: Q9H2X6

Source protein: Homeodomain-interacting protein kinase 2

Source gene: HIPK2

Class: DEG_SCF_FBW7_1

Location: 877:884

E3 ligase: FBXW7

DEGRON score: 0.9984

ASA_SCORE: 69.475

COIL: 0.8725

CONS_SCORE: 0.4741

DSS_SCORE: 0.5807

HELIX: 0.0115

FCONS_SCORE: 1.1969

RIG_SCORE: 0.7023

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P878L	TCGA-A5-A0VQ	UCEC	TCGA	IPDTPSPT	DEG_SCF_FBW7_1	0.6471
p.P878L	DO42113	UCEC	ICGC	IPDTPSPT	DEG_SCF_FBW7_1	0.6471
p.T889A	TCGA-AO-A128	BRCA	TCGA	IPDTPSPT	DEG_SCF_FBW7_1	0.1944
p.T889A	DO5326	BRCA	ICGC	IPDTPSPT	DEG_SCF_FBW7_1	0.1944
p.R870W	TCGA-AX-A3FT	UCEC	TCGA	IPDTPSPT	DEG_SCF_FBW7_1	0.1389
p.R870W	DO40801	UCEC	ICGC	IPDTPSPT	DEG_SCF_FBW7_1	0.1389
p.I888N	TCGA-BR-4361	STAD	TCGA	IPDTPSPT	DEG_SCF_FBW7_1	0.2222
p.I888N	DO38887	STAD	ICGC	IPDTPSPT	DEG_SCF_FBW7_1	0.2222
p.S882G	DO233259	GACA	ICGC	IPDTPSPT	DEG_SCF_FBW7_1	0.6993
p.G892E	DO233224	GACA	ICGC	IPDTPSPT	DEG_SCF_FBW7_1	0.1111
p.S891C	DO228212	LICA	ICGC	IPDTPSPT	DEG_SCF_FBW7_1	0.1389
p.T894K	DO228952	LICA	ICGC	IPDTPSPT	DEG_SCF_FBW7_1	0.0556
p.S891R	DO229015	LICA	ICGC	IPDTPSPT	DEG_SCF_FBW7_1	0.1389
p.P878T	DO229029	LICA	ICGC	IPDTPSPT	DEG_SCF_FBW7_1	0.5919
p.P878S	DO222536	MELA	ICGC	IPDTPSPT	DEG_SCF_FBW7_1	0.5641
p.V887A	DO222567	MELA	ICGC	IPDTPSPT	DEG_SCF_FBW7_1	0.25
p.R868W	SIDM00351	Oral Cavity Carcinoma	GDSC	IPDTPSPT	DEG_SCF_FBW7_1	0.0833
p.R868W	SIDM01782	Oral Cavity Carcinoma	GDSC	IPDTPSPT	DEG_SCF_FBW7_1	0.0833
p.R868W	SAS	upper_aerodigestive_tract	COSMIC	IPDTPSPT	DEG_SCF_FBW7_1	0.0833
p.I875V	SIDM00864	Cervical Carcinoma	GDSC	IPDTPSPT	DEG_SCF_FBW7_1	0.2778
p.I875V	ACH-001341	Cervical Cancer	CCLE	IPDTPSPT	DEG_SCF_FBW7_1	0.2778
p.I875V	DoTc2-4510	cervix	COSMIC	IPDTPSPT	DEG_SCF_FBW7_1	0.2778
p.T894A	ACH-001063	Ovarian Cancer	CCLE	IPDTPSPT	DEG_SCF_FBW7_1	0.0556
p.N887K	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	IPDTPSPT	DEG_SCF_FBW7_1	0.25
p.S878T	NCI-H378	lung	COSMIC	IPDTPSPT	DEG_SCF_FBW7_1	0.7116
p.E869K	SNU-1040	large_intestine	COSMIC	IPDTPSPT	DEG_SCF_FBW7_1	0.1111

Drug responses associated with HIPK2 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.E136D (No)	GDSC	PI-103	186.6479
SIDM00951	LAML\|acute_myeloid_leukaemia	p.D502N (No)	GDSC	PI-103	1.081
SIDM00951	LAML\|acute_myeloid_leukaemia	p.I227T (No)	GDSC	PI-103	1.081
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G1184V (No)	GDSC	PI-103	0.1231
SIDM00680	COREAD\|large_intestine	p.R554Q (No)	GDSC	PI-103	131.335
SIDM01045	UCEC\|endometrium	p.L59fs*56 (No)	GDSC	PI-103	3.7811
SIDM00499	PRAD\|prostate	p.G45D (No)	GDSC	PI-103	0.3537
SIDM00145	ALL\|lymphoblastic_leukemia	p.N914K (No)	GDSC	PI-103	0.1685
SIDM00108	SKCM\|melanoma	p.H322Q (No)	GDSC	PI-103	2.1752
SIDM00351	HNSC\|head_and_neck	p.R868W (Yes)	GDSC	PI-103	1.0036
SIDM00976	SKCM\|melanoma	p.G348R (No)	GDSC	PI-103	0.2229
SIDM00045	STAD\|stomach	p.C658F (No)	GDSC	PI-103	0.7557
SIDM01107	SKCM\|melanoma	p.T602P (No)	GDSC	PI-103	57.4273
SIDM01007	ALL\|lymphoblastic_leukemia	p.H807R (No)	GDSC	PI-103	0.2023
SIDM01007	ALL\|lymphoblastic_leukemia	p.K805R (No)	GDSC	PI-103	0.2023
SIDM01073	UNCLASSIFIED\|hairy_cell_leukaemia	p.S142N (No)	GDSC	PI-103	0.2031
SIDM00742	LUAD\|lung_NSCLC_adenocarcinoma	p.H760R (No)	GDSC	PI-103	2.0651
SIDM00565	HNSC\|head_and_neck	p.V737M (No)	GDSC	PI-103	2.2952
SIDM00443	DLBC\|B_cell_lymphoma	p.R941C (No)	GDSC	PI-103	0.0219
SIDM00377	UNCLASSIFIED\|uterus	p.H540R (No)	GDSC	PI-103	2.6284
SIDM00498	COREAD\|large_intestine	p.I603V (No)	GDSC	PI-103	3.2887
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.A624V (No)	GDSC	PI-103	0.0783
SIDM01045	UCEC\|endometrium	p.V94E (No)	GDSC	PI-103	3.7811
SIDM00946	ALL\|T_cell_leukemia	p.V50M (No)	GDSC	PI-103	0.526
SIDM00864	CESC\|cervix	p.I875V (Yes)	GDSC	PI-103	23.1182
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.R433S (No)	GDSC	PI-103	131.0205
SIDM00217	COREAD\|large_intestine	p.A1178V (No)	GDSC	PI-103	1.8634
SIDM00217	COREAD\|large_intestine	p.E896K (No)	GDSC	PI-103	1.8634
SIDM01003	ALL\|lymphoblastic_leukemia	p.R497Q (No)	GDSC	PI-103	0.2158
SIDM00216	COREAD\|large_intestine	p.I146T (No)	GDSC	PI-103	20.9452
SIDM00596	UCEC\|endometrium	p.R498Q (No)	GDSC	PI-103	22.6646
SIDM00282	COREAD\|large_intestine	p.A719S (No)	GDSC	PI-103	28.6572
SIDM00660	COREAD\|large_intestine	p.A512V (No)	GDSC	PI-103	0.5852
SIDM00955	SKCM\|melanoma	p.T1022N (No)	GDSC	PI-103	14.8056
SIDM00783	COREAD\|large_intestine	p.R792W (No)	GDSC	PI-103	0.5867
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.I33V (No)	GDSC	PI-103	0.0974
SIDM00789	COREAD\|large_intestine	p.V67I (No)	GDSC	PI-103	0.8427
SIDM00534	COREAD\|large_intestine	p.V1121A (No)	GDSC	PI-103	137.3337
SIDM00149	SKCM\|melanoma	p.M635I (No)	GDSC	PI-103	3.9173
SIDM00545	SKCM\|melanoma	p.R1056Q (No)	GDSC	PI-103	9.7833
SIDM00545	SKCM\|melanoma	p.H524Y (No)	GDSC	PI-103	9.7833
SIDM00114	MESO\|mesothelioma	p.L716I (No)	GDSC	PI-103	6.8017
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R133H (No)	GDSC	PI-103	0.976
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.L108F (No)	GDSC	PI-103	0.2536
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.S317I (No)	GDSC	PI-103	17.6642
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.F500V (No)	GDSC	PI-103	1.0649
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.Y468N (No)	GDSC	PI-103	1.0649
SIDM00537	COREAD\|large_intestine	p.T125A (No)	GDSC	PI-103	32.6383
SIDM00799	GBM\|glioma	p.S1002Y (No)	GDSC	PI-103	54.1746
SIDM00496	THCA\|thyroid	p.Q747K (No)	GDSC	PI-103	0.4742
SIDM00878	BRCA\|breast	p.R833C (No)	GDSC	PI-103	0.1835

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IPDTPSPT

Degron related mutations and impact score

Drug responses associated with HIPK2 mutations

All proteins holding degron of IPDTPSPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SCF_FBW7_1	877:884	IPDTPSPT	FBXW7	0.9984	More...