DegronMD

Uniprot ID: Q9H2X6

Source protein: Homeodomain-interacting protein kinase 2

Source gene: HIPK2

Class: DEG_APCC_KENBOX_2

Location: 834:838

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9934

ASA_SCORE: 103.58

COIL: 0.8654

CONS_SCORE: 0.35

DSS_SCORE: 0.5726

HELIX: 0.0774

FCONS_SCORE: 1.0455

RIG_SCORE: 0.6746

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R841H	TCGA-AA-A02O	COAD	TCGA	VKENT	DEG_APCC_KENBOX_2	0.25
p.R841H	DO9226	COAD	ICGC	VKENT	DEG_APCC_KENBOX_2	0.25
p.R841H	DO229039	LICA	ICGC	VKENT	DEG_APCC_KENBOX_2	0.25
p.R841C	TCGA-CV-A6K1	HNSC	TCGA	VKENT	DEG_APCC_KENBOX_2	0.25
p.R841C	DO234204	ESAD	ICGC	VKENT	DEG_APCC_KENBOX_2	0.25
p.R841C	DO52078	HNSC	ICGC	VKENT	DEG_APCC_KENBOX_2	0.25
p.P839T	DO228952	LICA	ICGC	VKENT	DEG_APCC_KENBOX_2	0.3056
p.A824D	DO229027	LICA	ICGC	VKENT	DEG_APCC_KENBOX_2	0.0556
p.M844I	DO229259	THCA	ICGC	VKENT	DEG_APCC_KENBOX_2	0.1667
p.I825M	DO229540	UTCA	ICGC	VKENT	DEG_APCC_KENBOX_2	0.0833
p.R833C	SIDM00878	Breast Carcinoma	GDSC	VKENT	DEG_APCC_KENBOX_2	0.3056
p.R833C	ACH-000930	Breast Cancer	CCLE	VKENT	DEG_APCC_KENBOX_2	0.3056
p.R833C	HCC1569	breast	COSMIC	VKENT	DEG_APCC_KENBOX_2	0.3056
p.R834C	NU-DUL-1	haematopoietic_and_lymphoid_tissue	COSMIC	VKENT	DEG_APCC_KENBOX_2	0.8301
p.I848V	DoTc2-4510	cervix	COSMIC	VKENT	DEG_APCC_KENBOX_2	0.5
p.R841W	SAS	upper_aerodigestive_tract	COSMIC	VKENT	DEG_APCC_KENBOX_2	0.25

Drug responses associated with HIPK2 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.E136D (No)	GDSC	PI-103	186.6479
SIDM00951	LAML\|acute_myeloid_leukaemia	p.D502N (No)	GDSC	PI-103	1.081
SIDM00951	LAML\|acute_myeloid_leukaemia	p.I227T (No)	GDSC	PI-103	1.081
SIDM00939	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G1184V (No)	GDSC	PI-103	0.1231
SIDM00680	COREAD\|large_intestine	p.R554Q (No)	GDSC	PI-103	131.335
SIDM01045	UCEC\|endometrium	p.L59fs*56 (No)	GDSC	PI-103	3.7811
SIDM00499	PRAD\|prostate	p.G45D (No)	GDSC	PI-103	0.3537
SIDM00145	ALL\|lymphoblastic_leukemia	p.N914K (No)	GDSC	PI-103	0.1685
SIDM00108	SKCM\|melanoma	p.H322Q (No)	GDSC	PI-103	2.1752
SIDM00351	HNSC\|head_and_neck	p.R868W (No)	GDSC	PI-103	1.0036
SIDM00976	SKCM\|melanoma	p.G348R (No)	GDSC	PI-103	0.2229
SIDM00045	STAD\|stomach	p.C658F (No)	GDSC	PI-103	0.7557
SIDM01107	SKCM\|melanoma	p.T602P (No)	GDSC	PI-103	57.4273
SIDM01007	ALL\|lymphoblastic_leukemia	p.H807R (No)	GDSC	PI-103	0.2023
SIDM01007	ALL\|lymphoblastic_leukemia	p.K805R (No)	GDSC	PI-103	0.2023
SIDM01073	UNCLASSIFIED\|hairy_cell_leukaemia	p.S142N (No)	GDSC	PI-103	0.2031
SIDM00742	LUAD\|lung_NSCLC_adenocarcinoma	p.H760R (No)	GDSC	PI-103	2.0651
SIDM00565	HNSC\|head_and_neck	p.V737M (No)	GDSC	PI-103	2.2952
SIDM00443	DLBC\|B_cell_lymphoma	p.R941C (No)	GDSC	PI-103	0.0219
SIDM00377	UNCLASSIFIED\|uterus	p.H540R (No)	GDSC	PI-103	2.6284
SIDM00498	COREAD\|large_intestine	p.I603V (No)	GDSC	PI-103	3.2887
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.A624V (No)	GDSC	PI-103	0.0783
SIDM01045	UCEC\|endometrium	p.V94E (No)	GDSC	PI-103	3.7811
SIDM00946	ALL\|T_cell_leukemia	p.V50M (No)	GDSC	PI-103	0.526
SIDM00864	CESC\|cervix	p.I875V (No)	GDSC	PI-103	23.1182
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.R433S (No)	GDSC	PI-103	131.0205
SIDM00217	COREAD\|large_intestine	p.A1178V (No)	GDSC	PI-103	1.8634
SIDM00217	COREAD\|large_intestine	p.E896K (No)	GDSC	PI-103	1.8634
SIDM01003	ALL\|lymphoblastic_leukemia	p.R497Q (No)	GDSC	PI-103	0.2158
SIDM00216	COREAD\|large_intestine	p.I146T (No)	GDSC	PI-103	20.9452
SIDM00596	UCEC\|endometrium	p.R498Q (No)	GDSC	PI-103	22.6646
SIDM00282	COREAD\|large_intestine	p.A719S (No)	GDSC	PI-103	28.6572
SIDM00660	COREAD\|large_intestine	p.A512V (No)	GDSC	PI-103	0.5852
SIDM00955	SKCM\|melanoma	p.T1022N (No)	GDSC	PI-103	14.8056
SIDM00783	COREAD\|large_intestine	p.R792W (No)	GDSC	PI-103	0.5867
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.I33V (No)	GDSC	PI-103	0.0974
SIDM00789	COREAD\|large_intestine	p.V67I (No)	GDSC	PI-103	0.8427
SIDM00534	COREAD\|large_intestine	p.V1121A (No)	GDSC	PI-103	137.3337
SIDM00149	SKCM\|melanoma	p.M635I (No)	GDSC	PI-103	3.9173
SIDM00545	SKCM\|melanoma	p.R1056Q (No)	GDSC	PI-103	9.7833
SIDM00545	SKCM\|melanoma	p.H524Y (No)	GDSC	PI-103	9.7833
SIDM00114	MESO\|mesothelioma	p.L716I (No)	GDSC	PI-103	6.8017
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R133H (No)	GDSC	PI-103	0.976
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.L108F (No)	GDSC	PI-103	0.2536
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.S317I (No)	GDSC	PI-103	17.6642
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.F500V (No)	GDSC	PI-103	1.0649
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.Y468N (No)	GDSC	PI-103	1.0649
SIDM00537	COREAD\|large_intestine	p.T125A (No)	GDSC	PI-103	32.6383
SIDM00799	GBM\|glioma	p.S1002Y (No)	GDSC	PI-103	54.1746
SIDM00496	THCA\|thyroid	p.Q747K (No)	GDSC	PI-103	0.4742
SIDM00878	BRCA\|breast	p.R833C (Yes)	GDSC	PI-103	0.1835

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68CZ1	Protein fantom	DEG_APCC_KENBOX_2	1030:1034	VKENT	APC,CDC20,FZR1	0.5377	More...
Q9BX40	Protein LSM14 homolog B	DEG_APCC_KENBOX_2	242:246	VKENT	APC,CDC20,FZR1	0.5991	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_APCC_KENBOX_2	834:838	VKENT	APC,CDC20,FZR1	0.9934	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VKENT

Degron related mutations and impact score

Drug responses associated with HIPK2 mutations

All proteins holding degron of VKENT