DegronMD

Uniprot ID: Q9H2X6

Source protein: Homeodomain-interacting protein kinase 2

Source gene: HIPK2

Class: DEG_APCC_KENBOX_2

Location: 834:838

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9934

ASA_SCORE: 103.58

COIL: 0.8654

CONS_SCORE: 0.35

DSS_SCORE: 0.5726

HELIX: 0.0774

FCONS_SCORE: 1.0455

RIG_SCORE: 0.6746

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R834C	NU-DUL-1	haematopoietic_and_lymphoid_tissue	COSMIC	VKENT	DEG_APCC_KENBOX_2	0.8301
p.I848V	DoTc2-4510	cervix	COSMIC	VKENT	DEG_APCC_KENBOX_2	0.5
p.P839T	DO228952	LICA	ICGC	VKENT	DEG_APCC_KENBOX_2	0.3056
p.R833C	SIDM00878	Breast Carcinoma	GDSC	VKENT	DEG_APCC_KENBOX_2	0.3056
p.R833C	ACH-000930	Breast Cancer	CCLE	VKENT	DEG_APCC_KENBOX_2	0.3056
p.R833C	HCC1569	breast	COSMIC	VKENT	DEG_APCC_KENBOX_2	0.3056
p.R841H	TCGA-AA-A02O	COAD	TCGA	VKENT	DEG_APCC_KENBOX_2	0.25
p.R841H	DO9226	COAD	ICGC	VKENT	DEG_APCC_KENBOX_2	0.25
p.R841H	DO229039	LICA	ICGC	VKENT	DEG_APCC_KENBOX_2	0.25
p.R841C	TCGA-CV-A6K1	HNSC	TCGA	VKENT	DEG_APCC_KENBOX_2	0.25
p.R841C	DO234204	ESAD	ICGC	VKENT	DEG_APCC_KENBOX_2	0.25
p.R841C	DO52078	HNSC	ICGC	VKENT	DEG_APCC_KENBOX_2	0.25
p.R841W	SAS	upper_aerodigestive_tract	COSMIC	VKENT	DEG_APCC_KENBOX_2	0.25
p.M844I	DO229259	THCA	ICGC	VKENT	DEG_APCC_KENBOX_2	0.1667
p.I825M	DO229540	UTCA	ICGC	VKENT	DEG_APCC_KENBOX_2	0.0833
p.A824D	DO229027	LICA	ICGC	VKENT	DEG_APCC_KENBOX_2	0.0556

Showing 1 to 16 of 16 entries

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Drug responses associated with HIPK2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00145	ALL\|lymphoblastic_leukemia	p.N914K (No)	GDSC	PI-103	0.1685
SIDM01007	ALL\|lymphoblastic_leukemia	p.H807R (No)	GDSC	PI-103	0.2023
SIDM01007	ALL\|lymphoblastic_leukemia	p.K805R (No)	GDSC	PI-103	0.2023
SIDM01003	ALL\|lymphoblastic_leukemia	p.R497Q (No)	GDSC	PI-103	0.2158
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R133H (No)	GDSC	PI-103	0.976
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.L108F (No)	GDSC	PI-103	0.2536
SIDM00946	ALL\|T_cell_leukemia	p.V50M (No)	GDSC	PI-103	0.526
SIDM00878	BRCA\|breast	p.R833C (Yes)	GDSC	PI-103	0.1835
SIDM00864	CESC\|cervix	p.I875V (No)	GDSC	PI-103	23.1182
SIDM00680	COREAD\|large_intestine	p.R554Q (No)	GDSC	PI-103	131.335
SIDM00498	COREAD\|large_intestine	p.I603V (No)	GDSC	PI-103	3.2887
SIDM00217	COREAD\|large_intestine	p.A1178V (No)	GDSC	PI-103	1.8634
SIDM00217	COREAD\|large_intestine	p.E896K (No)	GDSC	PI-103	1.8634
SIDM00216	COREAD\|large_intestine	p.I146T (No)	GDSC	PI-103	20.9452
SIDM00282	COREAD\|large_intestine	p.A719S (No)	GDSC	PI-103	28.6572
SIDM00660	COREAD\|large_intestine	p.A512V (No)	GDSC	PI-103	0.5852
SIDM00783	COREAD\|large_intestine	p.R792W (No)	GDSC	PI-103	0.5867
SIDM00789	COREAD\|large_intestine	p.V67I (No)	GDSC	PI-103	0.8427
SIDM00534	COREAD\|large_intestine	p.V1121A (No)	GDSC	PI-103	137.3337
SIDM00537	COREAD\|large_intestine	p.T125A (No)	GDSC	PI-103	32.6383
SIDM00443	DLBC\|B_cell_lymphoma	p.R941C (No)	GDSC	PI-103	0.0219
SIDM00799	GBM\|glioma	p.S1002Y (No)	GDSC	PI-103	54.1746
SIDM00351	HNSC\|head_and_neck	p.R868W (No)	GDSC	PI-103	1.0036
SIDM00565	HNSC\|head_and_neck	p.V737M (No)	GDSC	PI-103	2.2952
SIDM00951	LAML\|acute_myeloid_leukaemia	p.D502N (No)	GDSC	PI-103	1.081

Showing 1 to 25 of 51 entries

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All proteins holding degron of VKENT

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_APCC_KENBOX_2	834:838	VKENT	APC,CDC20,FZR1	0.9934	More...
Q68CZ1	Protein fantom	DEG_APCC_KENBOX_2	1030:1034	VKENT	APC,CDC20,FZR1	0.5377	More...
Q9BX40	Protein LSM14 homolog B	DEG_APCC_KENBOX_2	242:246	VKENT	APC,CDC20,FZR1	0.5991	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VKENT

Degron related mutations and impact score

Drug responses associated with HIPK2 mutations

All proteins holding degron of VKENT