DegronMD - Q9BX40(LSM14B)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R238H	TCGA-D1-A103	UCEC	TCGA	VKENT	DEG_APCC_KENBOX_2	242:246	Mutation rewiring degron network	0.2222
p.R238H	DO42312	UCEC	ICGC	VKENT	DEG_APCC_KENBOX_2	242:246	Mutation rewiring degron network	0.2222
p.R238H	ACH-000702	Lymphoma	CCLE	VKENT	DEG_APCC_KENBOX_2	242:246	Mutation rewiring degron network	0.2222
p.I247T	TCGA-UZ-A9PX	KIRP	TCGA	VKENT	DEG_APCC_KENBOX_2	242:246	Mutation rewiring degron network	0.3056
p.I247T	DO219712	KIRP	ICGC	VKENT	DEG_APCC_KENBOX_2	242:246	Mutation rewiring degron network	0.3056
p.N241K	SIDM00584	Osteosarcoma	GDSC	VKENT	DEG_APCC_KENBOX_2	242:246	Mutation rewiring degron network	0.3056
p.N241K	ACH-002142	Bone Cancer	CCLE	VKENT	DEG_APCC_KENBOX_2	242:246	Mutation rewiring degron network	0.3056
p.N241K	HuO-3N1	bone	COSMIC	VKENT	DEG_APCC_KENBOX_2	242:246	Mutation rewiring degron network	0.3056
p.V242I	SIDM00210	Ovarian Carcinoma	GDSC	VKENT	DEG_APCC_KENBOX_2	242:246	Mutation altering degron motif	0.5965
p.V242I	ACH-000657	Ovarian Cancer	CCLE	VKENT	DEG_APCC_KENBOX_2	242:246	Mutation altering degron motif	0.5965
p.V242I	A2780	ovary	COSMIC	VKENT	DEG_APCC_KENBOX_2	242:246	Mutation altering degron motif	0.5965

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons