DegronMD

Uniprot ID: Q9BX40

Source protein: Protein LSM14 homolog B

Source gene: LSM14B

Class: DEG_APCC_KENBOX_2

Location: 242:246

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5991

ASA_SCORE: 94.34

COIL: 0.8352

CONS_SCORE: 0.2686

DSS_SCORE: 0.5979

HELIX: 0.0892

FCONS_SCORE: 0.5897

RIG_SCORE: 0.7076

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R238H	TCGA-D1-A103	UCEC	TCGA	VKENT	DEG_APCC_KENBOX_2	0.2222
p.R238H	DO42312	UCEC	ICGC	VKENT	DEG_APCC_KENBOX_2	0.2222
p.R238H	ACH-000702	Lymphoma	CCLE	VKENT	DEG_APCC_KENBOX_2	0.2222
p.I247T	TCGA-UZ-A9PX	KIRP	TCGA	VKENT	DEG_APCC_KENBOX_2	0.3056
p.I247T	DO219712	KIRP	ICGC	VKENT	DEG_APCC_KENBOX_2	0.3056
p.N241K	SIDM00584	Osteosarcoma	GDSC	VKENT	DEG_APCC_KENBOX_2	0.3056
p.N241K	ACH-002142	Bone Cancer	CCLE	VKENT	DEG_APCC_KENBOX_2	0.3056
p.N241K	HuO-3N1	bone	COSMIC	VKENT	DEG_APCC_KENBOX_2	0.3056
p.V242I	SIDM00210	Ovarian Carcinoma	GDSC	VKENT	DEG_APCC_KENBOX_2	0.5965
p.V242I	ACH-000657	Ovarian Cancer	CCLE	VKENT	DEG_APCC_KENBOX_2	0.5965
p.V242I	A2780	ovary	COSMIC	VKENT	DEG_APCC_KENBOX_2	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68CZ1	Protein fantom	DEG_APCC_KENBOX_2	1030:1034	VKENT	APC,CDC20,FZR1	0.5377	More...
Q9BX40	Protein LSM14 homolog B	DEG_APCC_KENBOX_2	242:246	VKENT	APC,CDC20,FZR1	0.5991	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_APCC_KENBOX_2	834:838	VKENT	APC,CDC20,FZR1	0.9934	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons