DegronMD

Uniprot ID: Q68CZ1

Source protein: Protein fantom

Source gene: RPGRIP1L

Class: DEG_APCC_KENBOX_2

Location: 1030:1034

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5377

ASA_SCORE: 88.14

COIL: 0.4732

CONS_SCORE: 0.6945

DSS_SCORE: 0.6789

HELIX: 0.4926

FCONS_SCORE: 1.0418

RIG_SCORE: 0.7314

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1032Q	TCGA-4Z-AA80	BLCA	TCGA	VKENT	DEG_APCC_KENBOX_2	0.6744
p.E1032Q	DO218986	BLCA	ICGC	VKENT	DEG_APCC_KENBOX_2	0.6744
p.E1035D	TCGA-66-2773	LUSC	TCGA	VKENT	DEG_APCC_KENBOX_2	0.3056
p.E1035D	DO26536	LUSC	ICGC	VKENT	DEG_APCC_KENBOX_2	0.3056
p.E1032K	TCGA-VS-A9UZ	CESC	TCGA	VKENT	DEG_APCC_KENBOX_2	0.7022
p.E1032K	DO51646	CESC	ICGC	VKENT	DEG_APCC_KENBOX_2	0.7022
p.G1025S	DO229016	COCA	ICGC	VKENT	DEG_APCC_KENBOX_2	0.1944
p.G1025S	DO229489	LAML	ICGC	VKENT	DEG_APCC_KENBOX_2	0.1944
p.G1025S	DO229505	LAML	ICGC	VKENT	DEG_APCC_KENBOX_2	0.1944
p.G1025S	DO228947	LICA	ICGC	VKENT	DEG_APCC_KENBOX_2	0.1944
p.G1025S	DO229047	LICA	ICGC	VKENT	DEG_APCC_KENBOX_2	0.1944
p.Q1038K	DO229029	LICA	ICGC	VKENT	DEG_APCC_KENBOX_2	0.2222
p.T1034A	SIDM01146	Gastric Carcinoma	GDSC	VKENT	DEG_APCC_KENBOX_2	0.6028
p.T1034A	NCI-SNU-1	stomach	COSMIC	VKENT	DEG_APCC_KENBOX_2	0.6028
p.S1026F	ACH-001536	Bile Duct Cancer	CCLE	VKENT	DEG_APCC_KENBOX_2	0.2222
p.E1034G	ACH-001838	Bile Duct Cancer	CCLE	VKENT	DEG_APCC_KENBOX_2	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68CZ1	Protein fantom	DEG_APCC_KENBOX_2	1030:1034	VKENT	APC,CDC20,FZR1	0.5377	More...
Q9BX40	Protein LSM14 homolog B	DEG_APCC_KENBOX_2	242:246	VKENT	APC,CDC20,FZR1	0.5991	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_APCC_KENBOX_2	834:838	VKENT	APC,CDC20,FZR1	0.9934	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons