DegronMD

Uniprot ID: O75475

Source protein: PC4 and SFRS1-interacting protein

Source gene: PSIP1

Class: LIG_APCC_ABBA_1

Location: 58:63

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5928

ASA_SCORE: 52.0333

COIL: 0.4553

CONS_SCORE: 0.6583

DSS_SCORE: 0.3893

HELIX: 0.4298

FCONS_SCORE: 1.0141

RIG_SCORE: 0.7983

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K65M	ACH-001068	Lymphoma	CCLE	IFPYSE	LIG_APCC_ABBA_1	0.7222
p.F59C	SIDM00118	Colorectal Carcinoma	GDSC	IFPYSE	LIG_APCC_ABBA_1	0.5996
p.F59C	ACH-001081	Colon/Colorectal Cancer	CCLE	IFPYSE	LIG_APCC_ABBA_1	0.5996
p.F59C	HCC2998	large_intestine	COSMIC	IFPYSE	LIG_APCC_ABBA_1	0.5996
p.K56N	TCGA-D3-A3C6	SKCM	TCGA	IFPYSE	LIG_APCC_ABBA_1	0.2778
p.K56N	DO37507	SKCM	ICGC	IFPYSE	LIG_APCC_ABBA_1	0.2778
p.K56R	DO50664	ORCA	ICGC	IFPYSE	LIG_APCC_ABBA_1	0.2778
p.K70Q	TCGA-BS-A0UF	UCEC	TCGA	IFPYSE	LIG_APCC_ABBA_1	0.25
p.K70Q	DO41488	UCEC	ICGC	IFPYSE	LIG_APCC_ABBA_1	0.25
p.G54E	DO23206	LINC	ICGC	IFPYSE	LIG_APCC_ABBA_1	0.2222
p.T50I	TCGA-BS-A0UV	UCEC	TCGA	IFPYSE	LIG_APCC_ABBA_1	0.1111
p.T50I	DO42793	UCEC	ICGC	IFPYSE	LIG_APCC_ABBA_1	0.1111

Showing 1 to 12 of 12 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75475	PC4 and SFRS1-interacting protein	LIG_APCC_ABBA_1	58:63	IFPYSE	APC,CDC20,FZR1	0.5928	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons