DegronMD

Uniprot ID: Q7Z7A1

Source protein: Centriolin

Source gene: CNTRL

Class: DEG_APCC_DBOX_1

Location: 673:681

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.581

ASA_SCORE: 100.8778

COIL: 0.0106

CONS_SCORE: 0.6135

DSS_SCORE: 0.475

HELIX: 0.9897

FCONS_SCORE: 1.0639

RIG_SCORE: 0.7758

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A667V	TCGA-B5-A3FC	UCEC	TCGA	MRKELAELE	DEG_APCC_DBOX_1	0.1667
p.A667V	DO41871	UCEC	ICGC	MRKELAELE	DEG_APCC_DBOX_1	0.1667
p.E681K	DO50437	ESAD	ICGC	MRKELAELE	DEG_APCC_DBOX_1	0.591
p.S682I	DO229018	LICA	ICGC	MRKELAELE	DEG_APCC_DBOX_1	0.3056
p.A683S	DO229026	LICA	ICGC	MRKELAELE	DEG_APCC_DBOX_1	0.2778
p.M668I	DO229041	LICA	ICGC	MRKELAELE	DEG_APCC_DBOX_1	0.1944
p.L684P	DO229272	THCA	ICGC	MRKELAELE	DEG_APCC_DBOX_1	0.25
p.N672I	SIDM01175	Other Sarcomas	GDSC	MRKELAELE	DEG_APCC_DBOX_1	0.3056
p.N672I	ACH-002309	Sarcoma	CCLE	MRKELAELE	DEG_APCC_DBOX_1	0.3056
p.N672I	SW684	soft_tissue	COSMIC	MRKELAELE	DEG_APCC_DBOX_1	0.3056
p.V666G	SIDM00164	Biliary Tract Carcinoma	GDSC	MRKELAELE	DEG_APCC_DBOX_1	0.1389
p.V666G	ACH-000209	Bile Duct Cancer	CCLE	MRKELAELE	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z7A1	Centriolin	DEG_APCC_DBOX_1	673:681	MRKELAELE	APC,CDC20,FZR1	0.581	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons