DegronMD - Q16587(ZNF74)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S30L	TCGA-AX-A0J1	UCEC	TCGA	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.2222
p.S30L	TCGA-EE-A29S	SKCM	TCGA	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.2222
p.S30L	DO37936	SKCM	ICGC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.2222
p.S30L	DO41199	UCEC	ICGC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.2222
p.E36K	TCGA-BT-A20O	BLCA	TCGA	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.0556
p.E36K	DO460	BLCA	ICGC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.0556
p.E36K	SIDM00568	Gastric Carcinoma	GDSC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.0556
p.E36K	SIDM00251	Gastric Carcinoma	GDSC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.0556
p.E36K	SIDM00381	Cervical Carcinoma	GDSC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.0556
p.S30W	TCGA-CC-A7II	LIHC	TCGA	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.2222
p.S30W	DO52182	LIHC	ICGC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.2222
p.N25S	TCGA-LL-A6FQ	BRCA	TCGA	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation altering degron motif	0.7069
p.N25S	DO50054	BRCA	ICGC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation altering degron motif	0.7069
p.L33F	DO12712	GBM	ICGC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.1389
p.S31P	DO49773	KIRP	ICGC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.1944
p.H24Y	DO229052	LICA	ICGC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation altering degron motif	0.7229
p.G14C	DO229009	LICA	ICGC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.1111
p.T31A	DO231866	LINC	ICGC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.1944
p.V28M	DO229177	LMS	ICGC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.2778
p.G36R	DO51761	STAD	ICGC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.0556
p.G14S	DO47785	STAD	ICGC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.1111
p.G33C	DO229213	THCA	ICGC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.1389
p.P18H	DO229234	THCA	ICGC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.2222
p.W32L	SIDM00797	Melanoma	GDSC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.1667
p.W32L	ACH-000788	Skin Cancer	CCLE	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.1667
p.W32L	A2058	skin	COSMIC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.1667
p.P35A	SIDM00797	Melanoma	GDSC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.0833
p.P35A	ACH-000788	Skin Cancer	CCLE	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.0833
p.P35A	A2058	skin	COSMIC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.0833
p.P18S	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.2222
p.P18S	ACH-000675	Lung Cancer	CCLE	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.2222
p.P18S	NCI-H1734	lung	COSMIC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation rewiring degron network	0.2222
p.S23F	NCI-H1734	lung	COSMIC	LKENL	DEG_APCC_KENBOX_2	22:26	Mutation altering degron motif	0.7982

Kaplan plot for ZNF74 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF74

UniProt ID: Q16587

Entrez ID: 7625

Protein name: Zinc finger protein 74 (Zinc finger protein 520) (hZNF7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF74 in