DegronMD

Uniprot ID: Q5VT52

Source protein: Regulation of nuclear pre-mRNA domain-containing protein 2

Source gene: RPRD2

Class: DEG_APCC_KENBOX_2

Location: 155:159

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6187

ASA_SCORE: 89.08

COIL: 0.3652

CONS_SCORE: 0.371

DSS_SCORE: 0.5757

HELIX: 0.6258

FCONS_SCORE: 1.0921

RIG_SCORE: 0.7518

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T148S	TCGA-3C-AALI	BRCA	TCGA	LKENL	DEG_APCC_KENBOX_2	0.1389
p.T148S	DO219589	BRCA	ICGC	LKENL	DEG_APCC_KENBOX_2	0.1389
p.P163L	TCGA-A5-A0G1	UCEC	TCGA	LKENL	DEG_APCC_KENBOX_2	0.2222
p.P163L	DO42472	UCEC	ICGC	LKENL	DEG_APCC_KENBOX_2	0.2222
p.N164D	TCGA-EO-A22R	UCEC	TCGA	LKENL	DEG_APCC_KENBOX_2	0.1944
p.N164D	DO42713	UCEC	ICGC	LKENL	DEG_APCC_KENBOX_2	0.1944
p.K157N	DO229050	LICA	ICGC	LKENL	DEG_APCC_KENBOX_2	0.6918
p.L167I	DO37523	SKCM	ICGC	LKENL	DEG_APCC_KENBOX_2	0.1111
p.S147Y	DO41799	UCEC	ICGC	LKENL	DEG_APCC_KENBOX_2	0.1111
p.K151T	SK-MEL-3	skin	COSMIC	LKENL	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13796	Protein Shroom2	DEG_APCC_KENBOX_2	1548:1552	LKENL	APC,CDC20,FZR1	0.8846	More...
Q16587	Zinc finger protein 74	DEG_APCC_KENBOX_2	22:26	LKENL	APC,CDC20,FZR1	0.6629	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_APCC_KENBOX_2	155:159	LKENL	APC,CDC20,FZR1	0.6187	More...
Q7Z7A1	Centriolin	DEG_APCC_KENBOX_2	2203:2207	LKENL	APC,CDC20,FZR1	0.7087	More...
Q8TF72	Protein Shroom3	DEG_APCC_KENBOX_2	1894:1898	LKENL	APC,CDC20,FZR1	0.8715	More...
Q8N1N0	C-type lectin domain family 4 member F	DEG_APCC_KENBOX_2	288:292	LKENL	APC,CDC20,FZR1	0.6441	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons