DegronMD

Uniprot ID: Q8N1N0

Source protein: C-type lectin domain family 4 member F

Source gene: CLEC4F

Class: DEG_APCC_KENBOX_2

Location: 288:292

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6441

ASA_SCORE: 99.06

COIL: 0.171

CONS_SCORE: 0.6476

DSS_SCORE: 0.4001

HELIX: 0.827

FCONS_SCORE: 1.0985

RIG_SCORE: 0.7691

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E290K	TCGA-71-8520	LUAD	TCGA	LKENL	DEG_APCC_KENBOX_2	0.7022
p.E290K	TCGA-BF-A9VF	SKCM	TCGA	LKENL	DEG_APCC_KENBOX_2	0.7022
p.E290K	TCGA-FW-A3R5	SKCM	TCGA	LKENL	DEG_APCC_KENBOX_2	0.7022
p.E290K	DO48882	LUAD	ICGC	LKENL	DEG_APCC_KENBOX_2	0.7022
p.E290K	DO37406	SKCM	ICGC	LKENL	DEG_APCC_KENBOX_2	0.7022
p.E290K	DO219458	SKCM	ICGC	LKENL	DEG_APCC_KENBOX_2	0.7022
p.I285M	TCGA-73-4662	LUAD	TCGA	LKENL	DEG_APCC_KENBOX_2	0.25
p.I285M	DO24790	LUAD	ICGC	LKENL	DEG_APCC_KENBOX_2	0.25
p.Q286H	TCGA-AJ-A3BH	UCEC	TCGA	LKENL	DEG_APCC_KENBOX_2	0.2778
p.Q286H	DO41638	UCEC	ICGC	LKENL	DEG_APCC_KENBOX_2	0.2778
p.L278F	TCGA-BA-5152	HNSC	TCGA	LKENL	DEG_APCC_KENBOX_2	0.0556
p.L278F	DO14393	HNSC	ICGC	LKENL	DEG_APCC_KENBOX_2	0.0556
p.Q293H	TCGA-DD-A115	LIHC	TCGA	LKENL	DEG_APCC_KENBOX_2	0.3056
p.Q293H	DO22911	LIHC	ICGC	LKENL	DEG_APCC_KENBOX_2	0.3056
p.Q293K	DO229022	LICA	ICGC	LKENL	DEG_APCC_KENBOX_2	0.3056
p.N294D	DO50842	LIRI	ICGC	LKENL	DEG_APCC_KENBOX_2	0.2778
p.S300F	DO222875	MELA	ICGC	LKENL	DEG_APCC_KENBOX_2	0.1111
p.G287R	DO222843	MELA	ICGC	LKENL	DEG_APCC_KENBOX_2	0.3056
p.N282S	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	LKENL	DEG_APCC_KENBOX_2	0.1667
p.N282S	ACH-000825	Lung Cancer	CCLE	LKENL	DEG_APCC_KENBOX_2	0.1667
p.N282S	HOP-92	lung	COSMIC	LKENL	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13796	Protein Shroom2	DEG_APCC_KENBOX_2	1548:1552	LKENL	APC,CDC20,FZR1	0.8846	More...
Q16587	Zinc finger protein 74	DEG_APCC_KENBOX_2	22:26	LKENL	APC,CDC20,FZR1	0.6629	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_APCC_KENBOX_2	155:159	LKENL	APC,CDC20,FZR1	0.6187	More...
Q7Z7A1	Centriolin	DEG_APCC_KENBOX_2	2203:2207	LKENL	APC,CDC20,FZR1	0.7087	More...
Q8TF72	Protein Shroom3	DEG_APCC_KENBOX_2	1894:1898	LKENL	APC,CDC20,FZR1	0.8715	More...
Q8N1N0	C-type lectin domain family 4 member F	DEG_APCC_KENBOX_2	288:292	LKENL	APC,CDC20,FZR1	0.6441	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons