DegronMD

Uniprot ID: Q13796

Source protein: Protein Shroom2

Source gene: SHROOM2

Class: DEG_SPOP_SBC_1

Location: 133:137

E3 ligase: SPOP

DEGRON score: 0.9831

ASA_SCORE: 87.56

COIL: 0.9276

CONS_SCORE: 0.2302

DSS_SCORE: 0.4653

HELIX: 0.0354

FCONS_SCORE: 0.7161

RIG_SCORE: 0.64

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A130V	TCGA-EO-A22U	UCEC	TCGA	PFTST	DEG_SPOP_SBC_1	0.25
p.A130V	DO43755	UCEC	ICGC	PFTST	DEG_SPOP_SBC_1	0.25
p.S125G	TCGA-EO-A3KX	UCEC	TCGA	PFTST	DEG_SPOP_SBC_1	0.5556
p.S125G	DO219774	UCEC	ICGC	PFTST	DEG_SPOP_SBC_1	0.5556
p.G145S	TCGA-OL-A5DA	BRCA	TCGA	PFTST	DEG_SPOP_SBC_1	0.1111
p.G145S	DO44121	BRCA	ICGC	PFTST	DEG_SPOP_SBC_1	0.1111
p.G145S	SIDM00489	Oral Cavity Carcinoma	GDSC	PFTST	DEG_SPOP_SBC_1	0.1111
p.G145S	SIDM00792	Small Cell Lung Carcinoma	GDSC	PFTST	DEG_SPOP_SBC_1	0.1111
p.G145S	NCI-H1688	lung	COSMIC	PFTST	DEG_SPOP_SBC_1	0.1111
p.G145S	Ca9-22	upper_aerodigestive_tract	COSMIC	PFTST	DEG_SPOP_SBC_1	0.1111
p.S142F	DO222364	BTCA	ICGC	PFTST	DEG_SPOP_SBC_1	0.1944
p.A131S	DO229019	LICA	ICGC	PFTST	DEG_SPOP_SBC_1	0.2778
p.C140F	DO229041	LICA	ICGC	PFTST	DEG_SPOP_SBC_1	0.25
p.P127L	DO229054	LICA	ICGC	PFTST	DEG_SPOP_SBC_1	0.1667
p.H126Q	DO232826	NACA	ICGC	PFTST	DEG_SPOP_SBC_1	0.1389
p.P133T	DO229253	THCA	ICGC	PFTST	DEG_SPOP_SBC_1	0.7031
p.T137A	SIDM00633	Breast Carcinoma	GDSC	PFTST	DEG_SPOP_SBC_1	0.7139
p.R146Q	SIDM00351	Oral Cavity Carcinoma	GDSC	PFTST	DEG_SPOP_SBC_1	0.0833
p.R146Q	SIDM01776	Plasma Cell Myeloma	GDSC	PFTST	DEG_SPOP_SBC_1	0.0833
p.R146Q	SAS	upper_aerodigestive_tract	COSMIC	PFTST	DEG_SPOP_SBC_1	0.0833
p.E128K	SIDM01588	Endometrial Carcinoma	GDSC	PFTST	DEG_SPOP_SBC_1	0.1944
p.E128K	ACH-000993	Endometrial/Uterine Cancer	CCLE	PFTST	DEG_SPOP_SBC_1	0.1944
p.E143K	Sarc9371	bone	COSMIC	PFTST	DEG_SPOP_SBC_1	0.1667
p.P124S	OVISE	ovary	COSMIC	PFTST	DEG_SPOP_SBC_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons