DegronMD

Uniprot ID: P55198

Source protein: Protein AF-17

Source gene: MLLT6

Class: DEG_SCF_FBW7_1

Location: 570:577

E3 ligase: FBXW7

DEGRON score: 0.9957

ASA_SCORE: 74.2625

COIL: 0.8161

CONS_SCORE: 0.4563

DSS_SCORE: 0.3901

HELIX: 0.0844

FCONS_SCORE: 1.0387

RIG_SCORE: 0.7271

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R568Q	TCGA-AP-A0LM	UCEC	TCGA	VCSTPLSS	DEG_SCF_FBW7_1	0.2778
p.R568Q	DO43306	UCEC	ICGC	VCSTPLSS	DEG_SCF_FBW7_1	0.2778
p.R568Q	ACH-000961	Endometrial/Uterine Cancer	CCLE	VCSTPLSS	DEG_SCF_FBW7_1	0.2778
p.S561F	TCGA-FS-A1ZZ	SKCM	TCGA	VCSTPLSS	DEG_SCF_FBW7_1	0.0833
p.S561F	DO37412	SKCM	ICGC	VCSTPLSS	DEG_SCF_FBW7_1	0.0833
p.G565R	TCGA-HU-A4H8	STAD	TCGA	VCSTPLSS	DEG_SCF_FBW7_1	0.1944
p.G565R	DO47869	STAD	ICGC	VCSTPLSS	DEG_SCF_FBW7_1	0.1944
p.L575F	TCGA-QR-A70H	PCPG	TCGA	VCSTPLSS	DEG_SCF_FBW7_1	0.587
p.P574T	SIDM00660	Colorectal Carcinoma	GDSC	VCSTPLSS	DEG_SCF_FBW7_1	0.7031
p.P574T	ACH-000985	Colon/Colorectal Cancer	CCLE	VCSTPLSS	DEG_SCF_FBW7_1	0.7031
p.R568W	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	VCSTPLSS	DEG_SCF_FBW7_1	0.2778
p.T585P	ACH-000348	Skin Cancer	CCLE	VCSTPLSS	DEG_SCF_FBW7_1	0.1111
p.T585P	ACH-000714	Myeloma	CCLE	VCSTPLSS	DEG_SCF_FBW7_1	0.1111
p.T585P	ACH-000918	Leukemia	CCLE	VCSTPLSS	DEG_SCF_FBW7_1	0.1111
p.T585P	ACH-002187	Kidney Cancer	CCLE	VCSTPLSS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55198	Protein AF-17	DEG_SCF_FBW7_1	570:577	VCSTPLSS	FBXW7	0.9957	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons