DegronMD

Uniprot ID: P55198

Source protein: Protein AF-17

Source gene: MLLT6

Class: DEG_COP1_1

Location: 261:271

E3 ligase: COP1

DEGRON score: 0.9534

ASA_SCORE: 81.9182

COIL: 0.928

CONS_SCORE: 0.4251

DSS_SCORE: 0.7195

HELIX: 0.027

FCONS_SCORE: 0.9321

RIG_SCORE: 0.6336

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S277L	TCGA-A5-A0G2	UCEC	TCGA	SILTPPVVPTA	DEG_COP1_1	0.1667
p.S277L	DO41235	UCEC	ICGC	SILTPPVVPTA	DEG_COP1_1	0.1667
p.S258L	TCGA-AP-A1DK	UCEC	TCGA	SILTPPVVPTA	DEG_COP1_1	0.6944
p.S258L	DO42033	UCEC	ICGC	SILTPPVVPTA	DEG_COP1_1	0.6944
p.S261N	DO232224	PBCA	ICGC	SILTPPVVPTA	DEG_COP1_1	0.818

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55198	Protein AF-17	DEG_COP1_1	261:271	SILTPPVVPTA	COP1	0.9534	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons