DegronMD

Uniprot ID: O95359

Source protein: Transforming acidic coiled-coil-containing protein 2

Source gene: TACC2

Class: DEG_COP1_1

Location: 1994:2003

E3 ligase: COP1

DEGRON score: 0.7733

ASA_SCORE: 83.54

COIL: 0.9314

CONS_SCORE: 0.5771

DSS_SCORE: 0.7922

HELIX: 0.0143

FCONS_SCORE: 1.0011

RIG_SCORE: 0.5853

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1998H	TCGA-55-6971	LUAD	TCGA	SETVPVPDGP	DEG_COP1_1	0.6583
p.G1991V	TCGA-86-8073	LUAD	TCGA	SETVPVPDGP	DEG_COP1_1	0.25
p.P2000T	TCGA-D3-A8GN	SKCM	TCGA	SETVPVPDGP	DEG_COP1_1	0.7031
p.P1987L	TCGA-D8-A27K	BRCA	TCGA	SETVPVPDGP	DEG_COP1_1	0.1389
p.G2002D	TCGA-EB-A41A	SKCM	TCGA	SETVPVPDGP	DEG_COP1_1	0.7198
p.G2002D	TCGA-FW-A3TV	SKCM	TCGA	SETVPVPDGP	DEG_COP1_1	0.7198
p.V1999A	TCGA-FI-A2D5	UCEC	TCGA	SETVPVPDGP	DEG_COP1_1	0.6936
p.F2013S	TCGA-JX-A3Q0	CESC	TCGA	SETVPVPDGP	DEG_COP1_1	0.0556
p.R2010C	DO50299	SKCM	ICGC	SETVPVPDGP	DEG_COP1_1	0.1389
p.A1986T	DO51774	STAD	ICGC	SETVPVPDGP	DEG_COP1_1	0.1111
p.R2004W	SIDM00410	Other Blood Cancers	GDSC	SETVPVPDGP	DEG_COP1_1	0.3056
p.R2004W	SIDM01086	B-Lymphoblastic Leukemia	GDSC	SETVPVPDGP	DEG_COP1_1	0.3056
p.R2004W	YT	haematopoietic_and_lymphoid_tissue	COSMIC	SETVPVPDGP	DEG_COP1_1	0.3056
p.R2004W	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	SETVPVPDGP	DEG_COP1_1	0.3056
p.R2004Q	ACH-000928	Endometrial/Uterine Cancer	CCLE	SETVPVPDGP	DEG_COP1_1	0.3056
p.R2008W	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	SETVPVPDGP	DEG_COP1_1	0.1944
p.R2008W	YT	haematopoietic_and_lymphoid_tissue	COSMIC	SETVPVPDGP	DEG_COP1_1	0.1944
p.N1997K	HOP-92	lung	COSMIC	SETVPVPDGP	DEG_COP1_1	0.6918

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_COP1_1	1994:2003	SETVPVPDGP	COP1	0.7733	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons