DegronMD

Uniprot ID: O95359

Source protein: Transforming acidic coiled-coil-containing protein 2

Source gene: TACC2

Class: DEG_SCF_FBW7_2

Location: 724:730

E3 ligase: FBXW7

DEGRON score: 0.8869

ASA_SCORE: 91.2

COIL: 0.9494

CONS_SCORE: 0.3733

DSS_SCORE: 0.6569

HELIX: 0.0216

FCONS_SCORE: 0.8672

RIG_SCORE: 0.7002

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P727H	TCGA-AA-3977	COAD	TCGA	PPTPVAE	DEG_SCF_FBW7_2	0.7694
p.P727H	DO8730	COAD	ICGC	PPTPVAE	DEG_SCF_FBW7_2	0.7694
p.P724L	TCGA-NI-A8LF	LIHC	TCGA	PPTPVAE	DEG_SCF_FBW7_2	0.6471
p.P724L	DO49715	LIHC	ICGC	PPTPVAE	DEG_SCF_FBW7_2	0.6471
p.G714D	DO219889	DLBC	ICGC	PPTPVAE	DEG_SCF_FBW7_2	0.0556
p.G714D	DO49046	HNSC	ICGC	PPTPVAE	DEG_SCF_FBW7_2	0.0556
p.G714D	DO50973	LICA	ICGC	PPTPVAE	DEG_SCF_FBW7_2	0.0556
p.A719V	DO28119	OV	ICGC	PPTPVAE	DEG_SCF_FBW7_2	0.1944
p.A719V	DO41235	UCEC	ICGC	PPTPVAE	DEG_SCF_FBW7_2	0.1944
p.P724S	DO229459	SKCA	ICGC	PPTPVAE	DEG_SCF_FBW7_2	0.6752
p.S737G	DO51776	STAD	ICGC	PPTPVAE	DEG_SCF_FBW7_2	0.1389
p.G715D	ACH-000563	Lung Cancer	CCLE	PPTPVAE	DEG_SCF_FBW7_2	0.0833
p.G715D	ACH-001670	Brain Cancer	CCLE	PPTPVAE	DEG_SCF_FBW7_2	0.0833
p.G715D	EBC-1	lung	COSMIC	PPTPVAE	DEG_SCF_FBW7_2	0.0833
p.G715D	TASK1	bone	COSMIC	PPTPVAE	DEG_SCF_FBW7_2	0.0833
p.G727D	TASK1	bone	COSMIC	PPTPVAE	DEG_SCF_FBW7_2	0.7198
p.G727D	EBC-1	lung	COSMIC	PPTPVAE	DEG_SCF_FBW7_2	0.7198
p.E725Q	CAL-148	breast	COSMIC	PPTPVAE	DEG_SCF_FBW7_2	0.6744
p.H729P	NCI-H2170	lung	COSMIC	PPTPVAE	DEG_SCF_FBW7_2	0.7694
p.H729P	NCI-H520	lung	COSMIC	PPTPVAE	DEG_SCF_FBW7_2	0.7694
p.P716L	KYSE-450	oesophagus	COSMIC	PPTPVAE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_SCF_FBW7_2	724:730	PPTPVAE	FBXW7	0.8869	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons