DegronMD

Uniprot ID: O95359

Source protein: Transforming acidic coiled-coil-containing protein 2

Source gene: TACC2

Class: DEG_APCC_DBOX_1

Location: 703:711

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5991

ASA_SCORE: 95.0111

COIL: 0.7261

CONS_SCORE: 0.4272

DSS_SCORE: 0.5686

HELIX: 0.2016

FCONS_SCORE: 1.04

RIG_SCORE: 0.709

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L693S	TCGA-AG-3891	READ	TCGA	SREGLGRME	DEG_APCC_DBOX_1	0.0556
p.L693S	DO36388	READ	ICGC	SREGLGRME	DEG_APCC_DBOX_1	0.0556
p.S712Y	TCGA-EO-A22X	UCEC	TCGA	SREGLGRME	DEG_APCC_DBOX_1	0.75
p.S712Y	DO43907	UCEC	ICGC	SREGLGRME	DEG_APCC_DBOX_1	0.75
p.R709I	TCGA-N8-A4PM	UCS	TCGA	SREGLGRME	DEG_APCC_DBOX_1	0.6991
p.Q702P	TCGA-P3-A6SX	HNSC	TCGA	SREGLGRME	DEG_APCC_DBOX_1	0.3056
p.Q702P	DO49051	HNSC	ICGC	SREGLGRME	DEG_APCC_DBOX_1	0.3056
p.G714D	DO219889	DLBC	ICGC	SREGLGRME	DEG_APCC_DBOX_1	0.25
p.G714D	DO49046	HNSC	ICGC	SREGLGRME	DEG_APCC_DBOX_1	0.25
p.G714D	DO50973	LICA	ICGC	SREGLGRME	DEG_APCC_DBOX_1	0.25
p.S712F	DO220906	MELA	ICGC	SREGLGRME	DEG_APCC_DBOX_1	0.75
p.A719V	DO28119	OV	ICGC	SREGLGRME	DEG_APCC_DBOX_1	0.1111
p.A719V	DO41235	UCEC	ICGC	SREGLGRME	DEG_APCC_DBOX_1	0.1111
p.S695L	DO41271	UCEC	ICGC	SREGLGRME	DEG_APCC_DBOX_1	0.1111
p.L708M	DO41361	UCEC	ICGC	SREGLGRME	DEG_APCC_DBOX_1	0.711
p.G706R	SIDM01018	Hodgkin's Lymphoma	GDSC	SREGLGRME	DEG_APCC_DBOX_1	0.6457
p.G706R	ACH-000815	Lymphoma	CCLE	SREGLGRME	DEG_APCC_DBOX_1	0.6457
p.G706R	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	SREGLGRME	DEG_APCC_DBOX_1	0.6457
p.G715D	ACH-000563	Lung Cancer	CCLE	SREGLGRME	DEG_APCC_DBOX_1	0.2222
p.G715D	ACH-001670	Brain Cancer	CCLE	SREGLGRME	DEG_APCC_DBOX_1	0.2222
p.G715D	EBC-1	lung	COSMIC	SREGLGRME	DEG_APCC_DBOX_1	0.2222
p.G715D	TASK1	bone	COSMIC	SREGLGRME	DEG_APCC_DBOX_1	0.2222
p.L701M	ACH-002289	Leukemia	CCLE	SREGLGRME	DEG_APCC_DBOX_1	0.2778
p.L701M	NK-92MI	haematopoietic_and_lymphoid_tissue	COSMIC	SREGLGRME	DEG_APCC_DBOX_1	0.2778
p.L713M	NK-92MI	haematopoietic_and_lymphoid_tissue	COSMIC	SREGLGRME	DEG_APCC_DBOX_1	0.2778
p.P716L	KYSE-450	oesophagus	COSMIC	SREGLGRME	DEG_APCC_DBOX_1	0.1944
p.V710I	NB-4	haematopoietic_and_lymphoid_tissue	COSMIC	SREGLGRME	DEG_APCC_DBOX_1	0.7076
p.P709S	SW684	soft_tissue	COSMIC	SREGLGRME	DEG_APCC_DBOX_1	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SREGLGRME

Degron related mutations and impact score

Drug responses associated with TACC2 mutations

All proteins holding degron of SREGLGRME

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_APCC_DBOX_1	703:711	SREGLGRME	APC,CDC20,FZR1	0.5991	More...