DegronMD

Uniprot ID: Q9H799

Source protein: Ciliogenesis and planar polarity effector 1

Source gene: CPLANE1

Class: DEG_APCC_DBOX_1

Location: 1458:1466

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9169

ASA_SCORE: 72.5667

COIL: 0.6434

CONS_SCORE: 0.5004

DSS_SCORE: 0.3943

HELIX: 0.2811

FCONS_SCORE: 1.2356

RIG_SCORE: 0.6978

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1448A	SIDM00373	Endometrial Carcinoma	GDSC	SRSTLTELG	DEG_APCC_DBOX_1	0.0556
p.V1448A	SNG-M	endometrium	COSMIC	SRSTLTELG	DEG_APCC_DBOX_1	0.0556
p.R1459T	SIDM01090	Colorectal Carcinoma	GDSC	SRSTLTELG	DEG_APCC_DBOX_1	0.7876
p.S1452F	SIDM00790	Non-Cancerous	GDSC	SRSTLTELG	DEG_APCC_DBOX_1	0.1667
p.S1452F	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	SRSTLTELG	DEG_APCC_DBOX_1	0.1667
p.T1463I	SIDM00900	Non-Cancerous	GDSC	SRSTLTELG	DEG_APCC_DBOX_1	0.5966
p.T1463I	ARH-77	haematopoietic_and_lymphoid_tissue	COSMIC	SRSTLTELG	DEG_APCC_DBOX_1	0.5966
p.Y1451F	SIDM01228	Melanoma	GDSC	SRSTLTELG	DEG_APCC_DBOX_1	0.5833
p.Y1451F	CHL-1	skin	COSMIC	SRSTLTELG	DEG_APCC_DBOX_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H799	Ciliogenesis and planar polarity effector 1	DEG_APCC_DBOX_1	1458:1466	SRSTLTELG	APC,CDC20,FZR1	0.9169	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons