DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
VATPGGT
Uniprot ID:
Q9H799
Source protein:
Ciliogenesis and planar polarity effector 1
Source gene:
CPLANE1
Class:
DEG_SCF_FBW7_1
Location:
1836:1842
E3 ligase:
FBXW7
DEGRON score:
0.9994
ASA_SCORE:
69.3429
COIL:
0.958
CONS_SCORE:
0.5988
DSS_SCORE:
0.6523
HELIX:
0.0213
FCONS_SCORE:
1.3153
RIG_SCORE:
0.6216
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E1844D
SIDM01377
Ovarian Carcinoma
GDSC
VATPGGT
DEG_SCF_FBW7_1
0.2778
p.C1852G
SIDM01591
Breast Carcinoma
GDSC
VATPGGT
DEG_SCF_FBW7_1
0.0556
Drug responses associated with CPLANE1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VATPGGT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H799
Ciliogenesis and planar polarity effector 1
DEG_SCF_FBW7_1
1836:1842
VATPGGT
FBXW7
0.9994
More...