DegronMD - Q8WWI1(LMO7)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R966H	TCGA-AA-3672	COAD	TCGA	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation rewiring degron network	0.1667
p.R966H	DO9010	COAD	ICGC	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation rewiring degron network	0.1667
p.R966H	ACH-002223	Brain Cancer	CCLE	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation rewiring degron network	0.1667
p.R966H	D-245MG	central nervous system	COSMIC	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation rewiring degron network	0.1667
p.R1038K	TCGA-D1-A15X	UCEC	TCGA	INQTPGKS	DEG_SCF_FBW7_1	1045:1052	Mutation rewiring degron network	0.1389
p.R1038K	DO43274	UCEC	ICGC	INQTPGKS	DEG_SCF_FBW7_1	1045:1052	Mutation rewiring degron network	0.1389
p.L959I	TCGA-D3-A3CE	SKCM	TCGA	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation altering degron motif	0.7174
p.L959I	DO37405	SKCM	ICGC	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation altering degron motif	0.7174
p.G1050E	TCGA-D3-A8GI	SKCM	TCGA	INQTPGKS	DEG_SCF_FBW7_1	1045:1052	Mutation altering degron motif	0.6087
p.G1050E	DO27943	ORCA	ICGC	INQTPGKS	DEG_SCF_FBW7_1	1045:1052	Mutation altering degron motif	0.6087
p.G1050E	DO50284	SKCM	ICGC	INQTPGKS	DEG_SCF_FBW7_1	1045:1052	Mutation altering degron motif	0.6087
p.Q965E	TCGA-E7-A7XN	BLCA	TCGA	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation rewiring degron network	0.1944
p.Q965E	DO51878	BLCA	ICGC	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation rewiring degron network	0.1944
p.Q1054E	TCGA-EB-A430	SKCM	TCGA	INQTPGKS	DEG_SCF_FBW7_1	1045:1052	Mutation rewiring degron network	0.2778
p.Q1054E	DO37906	SKCM	ICGC	INQTPGKS	DEG_SCF_FBW7_1	1045:1052	Mutation rewiring degron network	0.2778
p.P1217S	TCGA-ER-A194	SKCM	TCGA	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation rewiring degron network	0.1944
p.P1217S	DO47646	SKCM	ICGC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation rewiring degron network	0.1944
p.L1057F	TCGA-F4-6856	COAD	TCGA	INQTPGKS	DEG_SCF_FBW7_1	1045:1052	Mutation rewiring degron network	0.1944
p.L1057F	DO9114	COAD	ICGC	INQTPGKS	DEG_SCF_FBW7_1	1045:1052	Mutation rewiring degron network	0.1944
p.R1205H	TCGA-L5-A8NI	ESCA	TCGA	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation altering degron motif	0.8244
p.R1205H	DO233270	GACA	ICGC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation altering degron motif	0.8244
p.V943I	DO228483	BRCA	ICGC	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation rewiring degron network	0.0556
p.V943I	DO229013	COCA	ICGC	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation rewiring degron network	0.0556
p.V943I	DO229005	COCA	ICGC	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation rewiring degron network	0.0556
p.V943I	DO234285	ESAD	ICGC	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation rewiring degron network	0.0556
p.V943I	DO230659	LAML	ICGC	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation rewiring degron network	0.0556
p.V943I	DO231140	LAML	ICGC	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation rewiring degron network	0.0556
p.V943I	DO228941	LICA	ICGC	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation rewiring degron network	0.0556
p.V943I	DO230535	LUSC	ICGC	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation rewiring degron network	0.0556
p.H1196Q	DO229016	COCA	ICGC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation rewiring degron network	0.1111
p.R1205C	DO233867	GACA	ICGC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation altering degron motif	0.8301
p.R1205C	DO50953	LICA	ICGC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation altering degron motif	0.8301
p.A1207V	DO231123	LAML	ICGC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation altering degron motif	0.6936
p.W1201C	DO228976	LICA	ICGC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation rewiring degron network	0.25
p.S1208I	DO229026	LICA	ICGC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation altering degron motif	0.7341
p.Q1039H	DO229045	LICA	ICGC	INQTPGKS	DEG_SCF_FBW7_1	1045:1052	Mutation rewiring degron network	0.1667
p.V1058F	DO229009	LICA	ICGC	INQTPGKS	DEG_SCF_FBW7_1	1045:1052	Mutation rewiring degron network	0.1667
p.G1218E	DO222837	MELA	ICGC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation rewiring degron network	0.1667
p.R948W	DO227689	PBCA	ICGC	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation rewiring degron network	0.1944
p.Q1035H	DO47407	SKCM	ICGC	INQTPGKS	DEG_SCF_FBW7_1	1045:1052	Mutation rewiring degron network	0.0556
p.R1199H	SIDM01021	Glioblastoma	GDSC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation rewiring degron network	0.1944
p.R1199H	D-245MG	central nervous system	COSMIC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation rewiring degron network	0.1944
p.E1207D	SIDM00950	Pancreatic Carcinoma	GDSC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation altering degron motif	0.6758
p.E1207D	SIDM00467	Acute Myeloid Leukemia	GDSC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation altering degron motif	0.6758
p.E1207D	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation altering degron motif	0.6758
p.H1587R	SIDM00183	Small Cell Lung Carcinoma	GDSC	VKTST	DEG_SPOP_SBC_1	1574:1578	Mutation rewiring degron network	0.0833
p.H1587R	SIDM01648	Non-Cancerous	GDSC	VKTST	DEG_SPOP_SBC_1	1574:1578	Mutation rewiring degron network	0.0833
p.L1580P	SIDM01088	Endometrial Carcinoma	GDSC	VKTST	DEG_SPOP_SBC_1	1574:1578	Mutation rewiring degron network	0.2778
p.L1580P	RL95-2	endometrium	COSMIC	VKTST	DEG_SPOP_SBC_1	1574:1578	Mutation rewiring degron network	0.2778
p.A1574T	SIDM00214	Colorectal Carcinoma	GDSC	VKTST	DEG_SPOP_SBC_1	1574:1578	Mutation altering degron motif	0.7139
p.A1574T	SNU-407	large intestine	COSMIC	VKTST	DEG_SPOP_SBC_1	1574:1578	Mutation altering degron motif	0.7139
p.A1215T	SIDM00826	Colorectal Carcinoma	GDSC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation rewiring degron network	0.25
p.A1215T	SIDM00823	Colorectal Carcinoma	GDSC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation rewiring degron network	0.25
p.A1215T	COLO-205	large intestine	COSMIC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation rewiring degron network	0.25
p.H1587Y	SIDM00217	Colorectal Carcinoma	GDSC	VKTST	DEG_SPOP_SBC_1	1574:1578	Mutation rewiring degron network	0.0833
p.H1587Y	SNU-1040	large intestine	COSMIC	VKTST	DEG_SPOP_SBC_1	1574:1578	Mutation rewiring degron network	0.0833
p.S1469Y	SIDM01611	Endometrial Carcinoma	GDSC	RTPLHND	LIG_APCC_ABBAyCdc20_2	1477:1483	Mutation rewiring degron network	0.1111
p.R948Q	ACH-000767	Lung Cancer	CCLE	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation rewiring degron network	0.1944
p.R948Q	NCI-H526	lung	COSMIC	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation rewiring degron network	0.1944
p.E955G	ACH-000898	Gastric Cancer	CCLE	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation altering degron motif	0.7199
p.P1040S	ACH-000985	Colon/Colorectal Cancer	CCLE	INQTPGKS	DEG_SCF_FBW7_1	1045:1052	Mutation rewiring degron network	0.1944
p.P1040S	LS-411N	large intestine	COSMIC	INQTPGKS	DEG_SCF_FBW7_1	1045:1052	Mutation rewiring degron network	0.1944
p.S1208N	ACH-002207	Skin Cancer	CCLE	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation altering degron motif	0.7069
p.S1208N	WM35	skin	COSMIC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation altering degron motif	0.7069
p.E1036D	ACH-002253	Lymphoma	CCLE	INQTPGKS	DEG_SCF_FBW7_1	1045:1052	Mutation rewiring degron network	0.0833
p.E1036D	JSC-1	haematopoietic and lymphoid tissue	COSMIC	INQTPGKS	DEG_SCF_FBW7_1	1045:1052	Mutation rewiring degron network	0.0833
p.S1478N	WM35	skin	COSMIC	RTPLHND	LIG_APCC_ABBAyCdc20_2	1477:1483	Mutation altering degron motif	0.7069
p.P1213R	ECC12	stomach	COSMIC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation rewiring degron network	0.3056
p.P1213R	GCIY	stomach	COSMIC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation rewiring degron network	0.3056
p.K963R	GR-ST	haematopoietic and lymphoid tissue	COSMIC	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation rewiring degron network	0.25
p.M1220V	T98G	central nervous system	COSMIC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation rewiring degron network	0.1111
p.P1205L	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation altering degron motif	0.7582
p.R1218Q	NCI-H526	lung	COSMIC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation rewiring degron network	0.1667
p.Q945P	FTC-133	thyroid	COSMIC	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation rewiring degron network	0.1111
p.Q945R	GR-ST	haematopoietic and lymphoid tissue	COSMIC	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation rewiring degron network	0.1111
p.A1218T	SNU-407	large intestine	COSMIC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation rewiring degron network	0.1667
p.E951K	JSC-1	haematopoietic and lymphoid tissue	COSMIC	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation rewiring degron network	0.2778
p.I1049M	EN	endometrium	COSMIC	INQTPGKS	DEG_SCF_FBW7_1	1045:1052	Mutation altering degron motif	0.7618
p.R1216W	H2373	pleura	COSMIC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation blocking phosphorylation signal	0.6667
p.M1490V	T98G	central nervous system	COSMIC	RTPLHND	LIG_APCC_ABBAyCdc20_2	1477:1483	Mutation rewiring degron network	0.1389
p.N1197D	IMR-5	autonomic ganglia	COSMIC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation blocking phosphorylation signal	0.5833
p.I1212F	NCI-H650	lung	COSMIC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation altering degron motif	0.7415
p.E949K	JSC-1	haematopoietic and lymphoid tissue	COSMIC	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation blocking phosphorylation signal	0.6667
p.A1204V	LS-411N	large intestine	COSMIC	SSDSVVPDL	DEG_COP1_1	1204:1212	Mutation altering degron motif	0.6936
p.R946W	H2373	pleura	COSMIC	VVSTPAPS	DEG_SCF_FBW7_1	953:960	Mutation rewiring degron network	0.1389
p.R1051Q	NCI-H810	lung	COSMIC	INQTPGKS	DEG_SCF_FBW7_1	1045:1052	Mutation altering degron motif	0.7329
p.K1037R	GR-ST	haematopoietic and lymphoid tissue	COSMIC	INQTPGKS	DEG_SCF_FBW7_1	1045:1052	Mutation rewiring degron network	0.1111
p.I1568F	NCI-H650	lung	COSMIC	VKTST	DEG_SPOP_SBC_1	1574:1578	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LMO7

UniProt ID: Q8WWI1

Entrez ID: 4008

Protein name: LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LMO7 in