DegronMD

Uniprot ID: Q8WWI1

Source protein: LIM domain only protein 7

Source gene: LMO7

Class: DEG_SCF_FBW7_1

Location: 953:960

E3 ligase: FBXW7

DEGRON score: 0.978

ASA_SCORE: 83.0875

COIL: 0.9486

CONS_SCORE: 0.3053

DSS_SCORE: 0.6489

HELIX: 0.0158

FCONS_SCORE: 0.9335

RIG_SCORE: 0.6564

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R966H	TCGA-AA-3672	COAD	TCGA	VVSTPAPS	DEG_SCF_FBW7_1	0.1667
p.R966H	DO9010	COAD	ICGC	VVSTPAPS	DEG_SCF_FBW7_1	0.1667
p.R966H	ACH-002223	Brain Cancer	CCLE	VVSTPAPS	DEG_SCF_FBW7_1	0.1667
p.R966H	D-245MG	central_nervous_system	COSMIC	VVSTPAPS	DEG_SCF_FBW7_1	0.1667
p.L959I	TCGA-D3-A3CE	SKCM	TCGA	VVSTPAPS	DEG_SCF_FBW7_1	0.7174
p.L959I	DO37405	SKCM	ICGC	VVSTPAPS	DEG_SCF_FBW7_1	0.7174
p.Q965E	TCGA-E7-A7XN	BLCA	TCGA	VVSTPAPS	DEG_SCF_FBW7_1	0.1944
p.Q965E	DO51878	BLCA	ICGC	VVSTPAPS	DEG_SCF_FBW7_1	0.1944
p.V943I	DO228483	BRCA	ICGC	VVSTPAPS	DEG_SCF_FBW7_1	0.0556
p.V943I	DO229013	COCA	ICGC	VVSTPAPS	DEG_SCF_FBW7_1	0.0556
p.V943I	DO229005	COCA	ICGC	VVSTPAPS	DEG_SCF_FBW7_1	0.0556
p.V943I	DO234285	ESAD	ICGC	VVSTPAPS	DEG_SCF_FBW7_1	0.0556
p.V943I	DO230659	LAML	ICGC	VVSTPAPS	DEG_SCF_FBW7_1	0.0556
p.V943I	DO231140	LAML	ICGC	VVSTPAPS	DEG_SCF_FBW7_1	0.0556
p.V943I	DO228941	LICA	ICGC	VVSTPAPS	DEG_SCF_FBW7_1	0.0556
p.V943I	DO230535	LUSC	ICGC	VVSTPAPS	DEG_SCF_FBW7_1	0.0556
p.R948W	DO227689	PBCA	ICGC	VVSTPAPS	DEG_SCF_FBW7_1	0.1944
p.R948Q	ACH-000767	Lung Cancer	CCLE	VVSTPAPS	DEG_SCF_FBW7_1	0.1944
p.R948Q	NCI-H526	lung	COSMIC	VVSTPAPS	DEG_SCF_FBW7_1	0.1944
p.E955G	ACH-000898	Gastric Cancer	CCLE	VVSTPAPS	DEG_SCF_FBW7_1	0.7199
p.K963R	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	VVSTPAPS	DEG_SCF_FBW7_1	0.25
p.Q945P	FTC-133	thyroid	COSMIC	VVSTPAPS	DEG_SCF_FBW7_1	0.1111
p.Q945R	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	VVSTPAPS	DEG_SCF_FBW7_1	0.1111
p.E951K	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	VVSTPAPS	DEG_SCF_FBW7_1	0.2778
p.E949K	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	VVSTPAPS	DEG_SCF_FBW7_1	0.6667
p.R946W	H2373	pleura	COSMIC	VVSTPAPS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWI1	LIM domain only protein 7	DEG_SCF_FBW7_1	953:960	VVSTPAPS	FBXW7	0.978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VVSTPAPS

Degron related mutations and impact score

Drug responses associated with LMO7 mutations

All proteins holding degron of VVSTPAPS