DegronMD

Uniprot ID: Q8WWI1

Source protein: LIM domain only protein 7

Source gene: LMO7

Class: DEG_SCF_FBW7_1

Location: 1045:1052

E3 ligase: FBXW7

DEGRON score: 0.9956

ASA_SCORE: 82.8625

COIL: 0.8073

CONS_SCORE: 0.4089

DSS_SCORE: 0.3535

HELIX: 0.0483

FCONS_SCORE: 0.9937

RIG_SCORE: 0.7346

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1038K	TCGA-D1-A15X	UCEC	TCGA	INQTPGKS	DEG_SCF_FBW7_1	0.1389
p.R1038K	DO43274	UCEC	ICGC	INQTPGKS	DEG_SCF_FBW7_1	0.1389
p.G1050E	TCGA-D3-A8GI	SKCM	TCGA	INQTPGKS	DEG_SCF_FBW7_1	0.6087
p.G1050E	DO27943	ORCA	ICGC	INQTPGKS	DEG_SCF_FBW7_1	0.6087
p.G1050E	DO50284	SKCM	ICGC	INQTPGKS	DEG_SCF_FBW7_1	0.6087
p.Q1054E	TCGA-EB-A430	SKCM	TCGA	INQTPGKS	DEG_SCF_FBW7_1	0.2778
p.Q1054E	DO37906	SKCM	ICGC	INQTPGKS	DEG_SCF_FBW7_1	0.2778
p.L1057F	TCGA-F4-6856	COAD	TCGA	INQTPGKS	DEG_SCF_FBW7_1	0.1944
p.L1057F	DO9114	COAD	ICGC	INQTPGKS	DEG_SCF_FBW7_1	0.1944
p.Q1039H	DO229045	LICA	ICGC	INQTPGKS	DEG_SCF_FBW7_1	0.1667
p.V1058F	DO229009	LICA	ICGC	INQTPGKS	DEG_SCF_FBW7_1	0.1667
p.Q1035H	DO47407	SKCM	ICGC	INQTPGKS	DEG_SCF_FBW7_1	0.0556
p.P1040S	ACH-000985	Colon/Colorectal Cancer	CCLE	INQTPGKS	DEG_SCF_FBW7_1	0.1944
p.P1040S	LS-411N	large_intestine	COSMIC	INQTPGKS	DEG_SCF_FBW7_1	0.1944
p.E1036D	ACH-002253	Lymphoma	CCLE	INQTPGKS	DEG_SCF_FBW7_1	0.0833
p.E1036D	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	INQTPGKS	DEG_SCF_FBW7_1	0.0833
p.I1049M	EN	endometrium	COSMIC	INQTPGKS	DEG_SCF_FBW7_1	0.7618
p.R1051Q	NCI-H810	lung	COSMIC	INQTPGKS	DEG_SCF_FBW7_1	0.7329
p.K1037R	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	INQTPGKS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWI1	LIM domain only protein 7	DEG_SCF_FBW7_1	1045:1052	INQTPGKS	FBXW7	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons