DegronMD

Uniprot ID: Q8WWI1

Source protein: LIM domain only protein 7

Source gene: LMO7

Class: DEG_COP1_1

Location: 1204:1212

E3 ligase: COP1

DEGRON score: 0.9975

ASA_SCORE: 88.1111

COIL: 0.9428

CONS_SCORE: 0.3954

DSS_SCORE: 0.5032

HELIX: 0.0291

FCONS_SCORE: 0.8858

RIG_SCORE: 0.6759

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1217S	TCGA-ER-A194	SKCM	TCGA	SSDSVVPDL	DEG_COP1_1	0.1944
p.P1217S	DO47646	SKCM	ICGC	SSDSVVPDL	DEG_COP1_1	0.1944
p.R1205H	TCGA-L5-A8NI	ESCA	TCGA	SSDSVVPDL	DEG_COP1_1	0.8244
p.R1205H	DO233270	GACA	ICGC	SSDSVVPDL	DEG_COP1_1	0.8244
p.H1196Q	DO229016	COCA	ICGC	SSDSVVPDL	DEG_COP1_1	0.1111
p.R1205C	DO233867	GACA	ICGC	SSDSVVPDL	DEG_COP1_1	0.8301
p.R1205C	DO50953	LICA	ICGC	SSDSVVPDL	DEG_COP1_1	0.8301
p.A1207V	DO231123	LAML	ICGC	SSDSVVPDL	DEG_COP1_1	0.6936
p.W1201C	DO228976	LICA	ICGC	SSDSVVPDL	DEG_COP1_1	0.25
p.S1208I	DO229026	LICA	ICGC	SSDSVVPDL	DEG_COP1_1	0.7341
p.G1218E	DO222837	MELA	ICGC	SSDSVVPDL	DEG_COP1_1	0.1667
p.R1199H	SIDM01021	Glioblastoma	GDSC	SSDSVVPDL	DEG_COP1_1	0.1944
p.R1199H	D-245MG	central_nervous_system	COSMIC	SSDSVVPDL	DEG_COP1_1	0.1944
p.E1207D	SIDM00950	Pancreatic Carcinoma	GDSC	SSDSVVPDL	DEG_COP1_1	0.6758
p.E1207D	SIDM00467	Acute Myeloid Leukemia	GDSC	SSDSVVPDL	DEG_COP1_1	0.6758
p.E1207D	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	SSDSVVPDL	DEG_COP1_1	0.6758
p.A1215T	SIDM00826	Colorectal Carcinoma	GDSC	SSDSVVPDL	DEG_COP1_1	0.25
p.A1215T	SIDM00823	Colorectal Carcinoma	GDSC	SSDSVVPDL	DEG_COP1_1	0.25
p.A1215T	COLO-205	large_intestine	COSMIC	SSDSVVPDL	DEG_COP1_1	0.25
p.S1208N	ACH-002207	Skin Cancer	CCLE	SSDSVVPDL	DEG_COP1_1	0.7069
p.S1208N	WM35	skin	COSMIC	SSDSVVPDL	DEG_COP1_1	0.7069
p.P1213R	ECC12	stomach	COSMIC	SSDSVVPDL	DEG_COP1_1	0.3056
p.P1213R	GCIY	stomach	COSMIC	SSDSVVPDL	DEG_COP1_1	0.3056
p.M1220V	T98G	central_nervous_system	COSMIC	SSDSVVPDL	DEG_COP1_1	0.1111
p.P1205L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	SSDSVVPDL	DEG_COP1_1	0.7582
p.R1218Q	NCI-H526	lung	COSMIC	SSDSVVPDL	DEG_COP1_1	0.1667
p.A1218T	SNU-407	large_intestine	COSMIC	SSDSVVPDL	DEG_COP1_1	0.1667
p.R1216W	H2373	pleura	COSMIC	SSDSVVPDL	DEG_COP1_1	0.6667
p.N1197D	IMR-5	autonomic_ganglia	COSMIC	SSDSVVPDL	DEG_COP1_1	0.5833
p.I1212F	NCI-H650	lung	COSMIC	SSDSVVPDL	DEG_COP1_1	0.7415
p.A1204V	LS-411N	large_intestine	COSMIC	SSDSVVPDL	DEG_COP1_1	0.6936

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SSDSVVPDL

Degron related mutations and impact score

Drug responses associated with LMO7 mutations

All proteins holding degron of SSDSVVPDL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWI1	LIM domain only protein 7	DEG_COP1_1	1204:1212	SSDSVVPDL	COP1	0.9975	More...