DegronMD

Uniprot ID: Q8WWI1

Source protein: LIM domain only protein 7

Source gene: LMO7

Class: LIG_APCC_ABBAyCdc20_2

Location: 1477:1483

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9962

ASA_SCORE: 101.0571

COIL: 0.8677

CONS_SCORE: 0.3608

DSS_SCORE: 0.542

HELIX: 0.107

FCONS_SCORE: 0.9867

RIG_SCORE: 0.6917

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1469Y	SIDM01611	Endometrial Carcinoma	GDSC	RTPLHND	LIG_APCC_ABBAyCdc20_2	0.1111
p.S1478N	WM35	skin	COSMIC	RTPLHND	LIG_APCC_ABBAyCdc20_2	0.7069
p.M1490V	T98G	central_nervous_system	COSMIC	RTPLHND	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWI1	LIM domain only protein 7	LIG_APCC_ABBAyCdc20_2	1477:1483	RTPLHND	APC,CDC20,FZR1	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons