DegronMD

Uniprot ID: A4UGR9

Source protein: Xin actin-binding repeat-containing protein 2

Source gene: XIRP2

Class: DEG_SPOP_SBC_1

Location: 1274:1278

E3 ligase: SPOP

DEGRON score: 0.9434

ASA_SCORE: 73.52

COIL: 0.376

CONS_SCORE: 0.8961

DSS_SCORE: 0.3306

HELIX: 0.0328

FCONS_SCORE: 1.1266

RIG_SCORE: 0.7969

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1270E	TCGA-21-1079	LUSC	TCGA	VKTST	DEG_SPOP_SBC_1	0.2222
p.G1270E	DO26846	LUSC	ICGC	VKTST	DEG_SPOP_SBC_1	0.2222
p.D1271N	TCGA-3N-A9WC	SKCM	TCGA	VKTST	DEG_SPOP_SBC_1	0.3611
p.D1271N	DO51234	SKCM	ICGC	VKTST	DEG_SPOP_SBC_1	0.3611
p.E1280V	TCGA-60-2723	LUSC	TCGA	VKTST	DEG_SPOP_SBC_1	0.2778
p.E1280V	DO27152	LUSC	ICGC	VKTST	DEG_SPOP_SBC_1	0.2778
p.S1283Y	TCGA-AP-A059	UCEC	TCGA	VKTST	DEG_SPOP_SBC_1	0.6389
p.S1283Y	TCGA-CA-6718	COAD	TCGA	VKTST	DEG_SPOP_SBC_1	0.6389
p.S1283Y	TCGA-EO-A3B0	UCEC	TCGA	VKTST	DEG_SPOP_SBC_1	0.6389
p.S1283Y	DO7801	COAD	ICGC	VKTST	DEG_SPOP_SBC_1	0.6389
p.S1283Y	DO219773	UCEC	ICGC	VKTST	DEG_SPOP_SBC_1	0.6389
p.S1283Y	DO41361	UCEC	ICGC	VKTST	DEG_SPOP_SBC_1	0.6389
p.R1273I	TCGA-AR-A250	BRCA	TCGA	VKTST	DEG_SPOP_SBC_1	0.3056
p.R1273I	DO1802	BRCA	ICGC	VKTST	DEG_SPOP_SBC_1	0.3056
p.I1267R	TCGA-BR-4361	STAD	TCGA	VKTST	DEG_SPOP_SBC_1	0.1389
p.I1267R	DO38887	STAD	ICGC	VKTST	DEG_SPOP_SBC_1	0.1389
p.G1270V	TCGA-D3-A2JH	SKCM	TCGA	VKTST	DEG_SPOP_SBC_1	0.2222
p.G1270V	DO47263	SKCM	ICGC	VKTST	DEG_SPOP_SBC_1	0.2222
p.K1274N	TCGA-D3-A8GM	SKCM	TCGA	VKTST	DEG_SPOP_SBC_1	0.6918
p.K1274N	DO50288	SKCM	ICGC	VKTST	DEG_SPOP_SBC_1	0.6918
p.L1284I	TCGA-E9-A243	BRCA	TCGA	VKTST	DEG_SPOP_SBC_1	0.1667
p.L1284I	DO4803	BRCA	ICGC	VKTST	DEG_SPOP_SBC_1	0.1667
p.S1283F	TCGA-FR-A8YC	SKCM	TCGA	VKTST	DEG_SPOP_SBC_1	0.6389
p.S1283F	TCGA-FS-A4F9	SKCM	TCGA	VKTST	DEG_SPOP_SBC_1	0.6389
p.S1283F	DO50301	SKCM	ICGC	VKTST	DEG_SPOP_SBC_1	0.6389
p.S1283F	DO38069	SKCM	ICGC	VKTST	DEG_SPOP_SBC_1	0.6389
p.F1277S	TCGA-Z2-A8RT	SKCM	TCGA	VKTST	DEG_SPOP_SBC_1	0.7982
p.F1277S	DO51301	SKCM	ICGC	VKTST	DEG_SPOP_SBC_1	0.7982
p.G1269C	DO234151	ESAD	ICGC	VKTST	DEG_SPOP_SBC_1	0.1944
p.C1276F	DO229028	LICA	ICGC	VKTST	DEG_SPOP_SBC_1	0.7108
p.F1282S	DO50957	LICA	ICGC	VKTST	DEG_SPOP_SBC_1	0.2222
p.D1285N	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	VKTST	DEG_SPOP_SBC_1	0.5833
p.D1285N	ACH-000951	Lung Cancer	CCLE	VKTST	DEG_SPOP_SBC_1	0.5833
p.D1285N	NCI-H2342	lung	COSMIC	VKTST	DEG_SPOP_SBC_1	0.5833
p.T1265I	SIDM00863	Burkitt's Lymphoma	GDSC	VKTST	DEG_SPOP_SBC_1	0.5278
p.E1280D	SIDM01611	Endometrial Carcinoma	GDSC	VKTST	DEG_SPOP_SBC_1	0.2778
p.R1275Q	HCC2998	large_intestine	COSMIC	VKTST	DEG_SPOP_SBC_1	0.7329
p.R1275Q	IGR-1	skin	COSMIC	VKTST	DEG_SPOP_SBC_1	0.7329
p.T1278S	DU-145	prostate	COSMIC	VKTST	DEG_SPOP_SBC_1	0.6005
p.T1276A	SNU-423	liver	COSMIC	VKTST	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_SPOP_SBC_1	1274:1278	VKTST	SPOP	0.9434	More...
O60293	Zinc finger C3H1 domain-containing protein	DEG_SPOP_SBC_1	411:415	VKTST	SPOP	0.9877	More...
Q8WWI1	LIM domain only protein 7	DEG_SPOP_SBC_1	1574:1578	VKTST	SPOP	0.975	More...
Q9H799	Ciliogenesis and planar polarity effector 1	DEG_SPOP_SBC_1	1777:1781	VKTST	SPOP	0.6764	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VKTST

Degron related mutations and impact score

Drug responses associated with XIRP2 mutations

All proteins holding degron of VKTST