DegronMD

Uniprot ID: O60293

Source protein: Zinc finger C3H1 domain-containing protein

Source gene: ZFC3H1

Class: DEG_APCC_DBOX_1

Location: 666:674

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8073

ASA_SCORE: 96.8556

COIL: 0.9058

CONS_SCORE: 0.4416

DSS_SCORE: 0.5263

HELIX: 0.0426

FCONS_SCORE: 1.0772

RIG_SCORE: 0.6791

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R667I	TCGA-AP-A1E0	UCEC	TCGA	PRSNLSIVS	DEG_APCC_DBOX_1	0.8102
p.R667I	DO43154	UCEC	ICGC	PRSNLSIVS	DEG_APCC_DBOX_1	0.8102
p.P664H	DO222743	MELA	ICGC	PRSNLSIVS	DEG_APCC_DBOX_1	0.2778
p.T677P	DO232224	PBCA	ICGC	PRSNLSIVS	DEG_APCC_DBOX_1	0.25
p.I672V	SIDM00194	Colorectal Carcinoma	GDSC	PRSNLSIVS	DEG_APCC_DBOX_1	0.5965
p.I672V	SNU-61	large_intestine	COSMIC	PRSNLSIVS	DEG_APCC_DBOX_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60293	Zinc finger C3H1 domain-containing protein	DEG_APCC_DBOX_1	666:674	PRSNLSIVS	APC,CDC20,FZR1	0.8073	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons