DegronMD

Uniprot ID: Q9H987

Source protein: Synaptopodin 2-like protein

Source gene: SYNPO2L

Class: DEG_SCF_FBW7_1

Location: 535:541

E3 ligase: FBXW7

DEGRON score: 0.9928

ASA_SCORE: 96.7143

COIL: 0.9727

CONS_SCORE: 0.4785

DSS_SCORE: 0.6522

HELIX: 0.0119

FCONS_SCORE: 0.9177

RIG_SCORE: 0.5203

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V544M	DO228991	LICA	ICGC	PSTPRSS	DEG_SCF_FBW7_1	0.25
p.V549M	LIM1215	large_intestine	COSMIC	PSTPRSS	DEG_SCF_FBW7_1	0.1111
p.R544H	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPRSS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H987	Synaptopodin 2-like protein	DEG_SCF_FBW7_1	535:541	PSTPRSS	FBXW7	0.9928	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons