DegronMD

Uniprot ID: Q5T0B9

Source protein: Zinc finger protein 362

Source gene: ZNF362

Class: DEG_SCF_FBW7_1

Location: 145:151

E3 ligase: FBXW7

DEGRON score: 0.9973

ASA_SCORE: 70.1286

COIL: 0.8657

CONS_SCORE: 0.5316

DSS_SCORE: 0.6888

HELIX: 0.0397

FCONS_SCORE: 1.2117

RIG_SCORE: 0.6433

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T151S	TCGA-BR-8078	STAD	TCGA	PSTPTTT	DEG_SCF_FBW7_1	0.6005
p.T151S	DO38288	STAD	ICGC	PSTPTTT	DEG_SCF_FBW7_1	0.6005
p.S160P	TCGA-5M-AAT6	COAD	TCGA	PSTPTTT	DEG_SCF_FBW7_1	0.5278
p.S160P	DO223703	COAD	ICGC	PSTPTTT	DEG_SCF_FBW7_1	0.5278
p.T140M	TCGA-DI-A2QU	UCEC	TCGA	PSTPTTT	DEG_SCF_FBW7_1	0.1944
p.T140M	DO233634	GACA	ICGC	PSTPTTT	DEG_SCF_FBW7_1	0.1944
p.T140M	DO42616	UCEC	ICGC	PSTPTTT	DEG_SCF_FBW7_1	0.1944
p.G139V	SIDM00962	Chronic Myelogenous Leukemia	GDSC	PSTPTTT	DEG_SCF_FBW7_1	0.1667
p.G139V	ACH-000432	Leukemia	CCLE	PSTPTTT	DEG_SCF_FBW7_1	0.1667
p.G139V	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPTTT	DEG_SCF_FBW7_1	0.1667
p.A158T	TCGA-CR-7382	HNSC	TCGA	PSTPTTT	DEG_SCF_FBW7_1	0.1389
p.A158T	DO14171	HNSC	ICGC	PSTPTTT	DEG_SCF_FBW7_1	0.1389
p.T138M	TCGA-D1-A174	UCEC	TCGA	PSTPTTT	DEG_SCF_FBW7_1	0.1389
p.T138M	DO40900	UCEC	ICGC	PSTPTTT	DEG_SCF_FBW7_1	0.1389
p.T138M	SIDM01051	Ovarian Carcinoma	GDSC	PSTPTTT	DEG_SCF_FBW7_1	0.1389
p.T138M	ACH-000936	Ovarian Cancer	CCLE	PSTPTTT	DEG_SCF_FBW7_1	0.1389
p.T138M	EFO-27	ovary	COSMIC	PSTPTTT	DEG_SCF_FBW7_1	0.1389
p.T138A	SIDM00889	Cervical Carcinoma	GDSC	PSTPTTT	DEG_SCF_FBW7_1	0.1389
p.T138A	ACH-001333	Cervical Cancer	CCLE	PSTPTTT	DEG_SCF_FBW7_1	0.1389
p.T138A	C-33-A	cervix	COSMIC	PSTPTTT	DEG_SCF_FBW7_1	0.1389
p.A136T	DO222973	BTCA	ICGC	PSTPTTT	DEG_SCF_FBW7_1	0.0833
p.A136T	SIDM01099	Neuroblastoma	GDSC	PSTPTTT	DEG_SCF_FBW7_1	0.0833
p.A136T	SIDM00879	Breast Carcinoma	GDSC	PSTPTTT	DEG_SCF_FBW7_1	0.0833
p.A136T	SIDM01147	Gastric Carcinoma	GDSC	PSTPTTT	DEG_SCF_FBW7_1	0.0833
p.A136T	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PSTPTTT	DEG_SCF_FBW7_1	0.0833

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Drug responses associated with ZNF362 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PSTPTTT

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T0B9	Zinc finger protein 362	DEG_SCF_FBW7_1	145:151	PSTPTTT	FBXW7	0.9973	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTPTTT

Degron related mutations and impact score

Drug responses associated with ZNF362 mutations

All proteins holding degron of PSTPTTT