DegronMD

Uniprot ID: A8CG34

Source protein: Nuclear envelope pore membrane protein POM 121C

Source gene: POM121C

Class: DEG_SPOP_SBC_1

Location: 1145:1149

E3 ligase: SPOP

DEGRON score: 0.989

ASA_SCORE: 75.56

COIL: 0.9424

CONS_SCORE: 0.6649

DSS_SCORE: 0.5009

HELIX: 0.0138

FCONS_SCORE: 0.8968

RIG_SCORE: 0.7123

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1141C	DO7801	COAD	ICGC	VGSTT	DEG_SPOP_SBC_1	0.2222
p.F1143L	DO8778	COAD	ICGC	VGSTT	DEG_SPOP_SBC_1	0.2778
p.G1146V	DO229250	THCA	ICGC	VGSTT	DEG_SPOP_SBC_1	0.6421
p.G1136S	DO41518	UCEC	ICGC	VGSTT	DEG_SPOP_SBC_1	0.0833
p.E1150Q	ACH-000685	Pancreatic Cancer	CCLE	VGSTT	DEG_SPOP_SBC_1	0.3056
p.A1159T	SNU-1040	large_intestine	COSMIC	VGSTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	1145:1149	VGSTT	SPOP	0.989	More...
P37275	Zinc finger E-box-binding homeobox 1	DEG_SPOP_SBC_1	691:695	VGSTT	SPOP	0.9133	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	5117:5121	VGSTT	SPOP	0.987	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	5127:5131	VGSTT	SPOP	0.9091	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2508:2512	VGSTT	SPOP	0.8332	More...
Q9UQ52	Contactin-6	DEG_SPOP_SBC_1	743:747	VGSTT	SPOP	0.8232	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	750:754	VGSTT	SPOP	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons