DegronMD

Uniprot ID: Q9UQ52

Source protein: Contactin-6

Source gene: CNTN6

Class: DEG_SPOP_SBC_1

Location: 743:747

E3 ligase: SPOP

DEGRON score: 0.8232

ASA_SCORE: 75.46

COIL: 0.8042

CONS_SCORE: 0.6493

DSS_SCORE: 0.1447

HELIX: 0.0318

FCONS_SCORE: 1.0253

RIG_SCORE: 0.7595

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G744V	TCGA-39-5040	LUSC	TCGA	VGSTT	DEG_SPOP_SBC_1	0.6421
p.S745L	TCGA-77-7337	LUSC	TCGA	VGSTT	DEG_SPOP_SBC_1	0.7667
p.S745L	TCGA-EO-A3B1	UCEC	TCGA	VGSTT	DEG_SPOP_SBC_1	0.7667
p.S745L	TCGA-ER-A193	SKCM	TCGA	VGSTT	DEG_SPOP_SBC_1	0.7667
p.S745L	SIDM00211	B-Lymphoblastic Leukemia	GDSC	VGSTT	DEG_SPOP_SBC_1	0.7667
p.R741W	TCGA-81-5911	GBM	TCGA	VGSTT	DEG_SPOP_SBC_1	0.2778
p.R741W	SIDM01197	Colorectal Carcinoma	GDSC	VGSTT	DEG_SPOP_SBC_1	0.2778
p.R741W	SIDM01470	Acute Myeloid Leukemia	GDSC	VGSTT	DEG_SPOP_SBC_1	0.2778
p.R741W	ACH-000387	Leukemia	CCLE	VGSTT	DEG_SPOP_SBC_1	0.2778
p.R741W	ACH-000722	Colon/Colorectal Cancer	CCLE	VGSTT	DEG_SPOP_SBC_1	0.2778
p.R741W	SNU-C1	large_intestine	COSMIC	VGSTT	DEG_SPOP_SBC_1	0.2778
p.G744D	TCGA-D5-6930	COAD	TCGA	VGSTT	DEG_SPOP_SBC_1	0.6087
p.W756L	DO10467	COAD	ICGC	VGSTT	DEG_SPOP_SBC_1	0.0833
p.P734S	DO7855	COAD	ICGC	VGSTT	DEG_SPOP_SBC_1	0.0833
p.A753V	DO8730	COAD	ICGC	VGSTT	DEG_SPOP_SBC_1	0.1667
p.S738Y	DO222800	COCA	ICGC	VGSTT	DEG_SPOP_SBC_1	0.1944
p.L739V	DO49040	HNSC	ICGC	VGSTT	DEG_SPOP_SBC_1	0.2222
p.E748D	DO22237	LGG	ICGC	VGSTT	DEG_SPOP_SBC_1	0.3056
p.N757I	DO228667	LICA	ICGC	VGSTT	DEG_SPOP_SBC_1	0.0556
p.G736E	DO220852	MELA	ICGC	VGSTT	DEG_SPOP_SBC_1	0.1389
p.G736E	DO229456	SKCA	ICGC	VGSTT	DEG_SPOP_SBC_1	0.1389
p.G736E	DO48665	SKCM	ICGC	VGSTT	DEG_SPOP_SBC_1	0.1389
p.G736E	DO37961	SKCM	ICGC	VGSTT	DEG_SPOP_SBC_1	0.1389
p.S750L	DO229453	SKCA	ICGC	VGSTT	DEG_SPOP_SBC_1	0.3611
p.G736R	DO47419	SKCM	ICGC	VGSTT	DEG_SPOP_SBC_1	0.1389
p.S741C	DO50132	STAD	ICGC	VGSTT	DEG_SPOP_SBC_1	0.2778
p.A733P	DO47837	STAD	ICGC	VGSTT	DEG_SPOP_SBC_1	0.0556
p.I738T	SIDM02025	Colorectal Carcinoma	GDSC	VGSTT	DEG_SPOP_SBC_1	0.1944
p.G735E	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	VGSTT	DEG_SPOP_SBC_1	0.1111
p.G735E	ACH-000264	Lung Cancer	CCLE	VGSTT	DEG_SPOP_SBC_1	0.1111
p.G735E	Calu-6	lung	COSMIC	VGSTT	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	1145:1149	VGSTT	SPOP	0.989	More...
P37275	Zinc finger E-box-binding homeobox 1	DEG_SPOP_SBC_1	691:695	VGSTT	SPOP	0.9133	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	5117:5121	VGSTT	SPOP	0.987	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	5127:5131	VGSTT	SPOP	0.9091	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2508:2512	VGSTT	SPOP	0.8332	More...
Q9UQ52	Contactin-6	DEG_SPOP_SBC_1	743:747	VGSTT	SPOP	0.8232	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	750:754	VGSTT	SPOP	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VGSTT

Degron related mutations and impact score

Drug responses associated with CNTN6 mutations

All proteins holding degron of VGSTT