DegronMD - Q9UQ52(CNTN6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G744V	TCGA-39-5040	LUSC	TCGA	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation altering degron motif	0.6421
p.S745L	TCGA-77-7337	LUSC	TCGA	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation altering degron motif	0.7667
p.S745L	TCGA-EO-A3B1	UCEC	TCGA	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation altering degron motif	0.7667
p.S745L	TCGA-ER-A193	SKCM	TCGA	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation altering degron motif	0.7667
p.S745L	SIDM00211	B-Lymphoblastic Leukemia	GDSC	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation altering degron motif	0.7667
p.R741W	TCGA-81-5911	GBM	TCGA	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.2778
p.R741W	SIDM01197	Colorectal Carcinoma	GDSC	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.2778
p.R741W	SIDM01470	Acute Myeloid Leukemia	GDSC	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.2778
p.R741W	ACH-000387	Leukemia	CCLE	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.2778
p.R741W	ACH-000722	Colon/Colorectal Cancer	CCLE	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.2778
p.R741W	SNU-C1	large intestine	COSMIC	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.2778
p.G744D	TCGA-D5-6930	COAD	TCGA	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation altering degron motif	0.6087
p.W756L	DO10467	COAD	ICGC	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.0833
p.P734S	DO7855	COAD	ICGC	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.0833
p.A753V	DO8730	COAD	ICGC	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.1667
p.S738Y	DO222800	COCA	ICGC	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.1944
p.L739V	DO49040	HNSC	ICGC	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.2222
p.E748D	DO22237	LGG	ICGC	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.3056
p.N757I	DO228667	LICA	ICGC	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.0556
p.G736E	DO220852	MELA	ICGC	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.1389
p.G736E	DO229456	SKCA	ICGC	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.1389
p.G736E	DO48665	SKCM	ICGC	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.1389
p.G736E	DO37961	SKCM	ICGC	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.1389
p.S750L	DO229453	SKCA	ICGC	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation substituting flanking lysine	0.3611
p.G736R	DO47419	SKCM	ICGC	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.1389
p.S741C	DO50132	STAD	ICGC	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.2778
p.A733P	DO47837	STAD	ICGC	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.0556
p.I738T	SIDM02025	Colorectal Carcinoma	GDSC	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.1944
p.G735E	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.1111
p.G735E	ACH-000264	Lung Cancer	CCLE	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.1111
p.G735E	Calu-6	lung	COSMIC	VGSTT	DEG_SPOP_SBC_1	743:747	Mutation rewiring degron network	0.1111

Kaplan plot for CNTN6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CNTN6

UniProt ID: Q9UQ52

Entrez ID: 27255

Protein name: Contactin-6 (Neural recognition molecule NB-3) (hNB-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CNTN6 in