DegronMD

Uniprot ID: P37275

Source protein: Zinc finger E-box-binding homeobox 1

Source gene: ZEB1

Class: DEG_SPOP_SBC_1

Location: 691:695

E3 ligase: SPOP

DEGRON score: 0.9133

ASA_SCORE: 84.72

COIL: 0.9442

CONS_SCORE: 0.2951

DSS_SCORE: 0.6938

HELIX: 0.021

FCONS_SCORE: 0.9053

RIG_SCORE: 0.5944

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P688T	TCGA-86-A456	LUAD	TCGA	VGSTT	DEG_SPOP_SBC_1	0.25
p.K683N	TCGA-A5-A2K5	UCEC	TCGA	VGSTT	DEG_SPOP_SBC_1	0.1111
p.G693E	TCGA-AN-A0FT	BRCA	TCGA	VGSTT	DEG_SPOP_SBC_1	0.7199
p.T703A	TCGA-B5-A11E	UCEC	TCGA	VGSTT	DEG_SPOP_SBC_1	0.1111
p.R700I	TCGA-D1-A17Q	UCEC	TCGA	VGSTT	DEG_SPOP_SBC_1	0.6389
p.P681S	TCGA-D9-A3Z1	SKCM	TCGA	VGSTT	DEG_SPOP_SBC_1	0.0556
p.S687F	TCGA-EE-A2A2	SKCM	TCGA	VGSTT	DEG_SPOP_SBC_1	0.2222
p.P700H	DO222517	BTCA	ICGC	VGSTT	DEG_SPOP_SBC_1	0.6389
p.Q690H	DO234199	ESAD	ICGC	VGSTT	DEG_SPOP_SBC_1	0.3056
p.Q690H	DO15390	HNSC	ICGC	VGSTT	DEG_SPOP_SBC_1	0.3056
p.V696F	DO229028	LICA	ICGC	VGSTT	DEG_SPOP_SBC_1	0.3056
p.C705F	DO26635	LUSC	ICGC	VGSTT	DEG_SPOP_SBC_1	0.0556
p.S704F	DO220239	SARC	ICGC	VGSTT	DEG_SPOP_SBC_1	0.5278
p.Q690K	DO37431	SKCM	ICGC	VGSTT	DEG_SPOP_SBC_1	0.3056
p.S695F	DO51276	SKCM	ICGC	VGSTT	DEG_SPOP_SBC_1	0.7982
p.S683P	DO51761	STAD	ICGC	VGSTT	DEG_SPOP_SBC_1	0.1111
p.P704S	SIDM00140	Melanoma	GDSC	VGSTT	DEG_SPOP_SBC_1	0.5278
p.P704S	COLO-792	skin	COSMIC	VGSTT	DEG_SPOP_SBC_1	0.5278
p.P703S	ACH-000968	Skin Cancer	CCLE	VGSTT	DEG_SPOP_SBC_1	0.1111
p.P703S	COLO-792	skin	COSMIC	VGSTT	DEG_SPOP_SBC_1	0.1111
p.L703V	HN	upper_aerodigestive_tract	COSMIC	VGSTT	DEG_SPOP_SBC_1	0.1111
p.T702I	LS-411N	large_intestine	COSMIC	VGSTT	DEG_SPOP_SBC_1	0.5833
p.P687S	COLO-792	skin	COSMIC	VGSTT	DEG_SPOP_SBC_1	0.2222
p.P683S	COLO-792	skin	COSMIC	VGSTT	DEG_SPOP_SBC_1	0.1111
p.S695Y	NCI-H345	lung	COSMIC	VGSTT	DEG_SPOP_SBC_1	0.712

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	1145:1149	VGSTT	SPOP	0.989	More...
P37275	Zinc finger E-box-binding homeobox 1	DEG_SPOP_SBC_1	691:695	VGSTT	SPOP	0.9133	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	5117:5121	VGSTT	SPOP	0.987	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	5127:5131	VGSTT	SPOP	0.9091	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2508:2512	VGSTT	SPOP	0.8332	More...
Q9UQ52	Contactin-6	DEG_SPOP_SBC_1	743:747	VGSTT	SPOP	0.8232	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	750:754	VGSTT	SPOP	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons