DegronMD - P37275(ZEB1)

FUNCTION: Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by... View more >>

GO - Biological processes (BP): anatomical structure development [GO:0048856]; cartilage development [GO:0051216]; cell differentiation [GO:0030154]; cellular response to amino acid stimulus [GO:0071230]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cochlea morphogenesis [GO:0090103]; embryonic camer... View more >>

GO - Molecular function (MF): chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; E-box binding [GO:0070888]; RNA polymeras... View more >>

GO - Cellular component (CC): chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S695F	DO51276	SKCM	ICGC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation altering degron motif	0.7982
p.P495H	DO48583	BLCA	ICGC	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation altering degron motif	0.7694
p.K494R	TCGA-50-5049	LUAD	TCGA	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation altering degron motif	0.7237
p.G693E	TCGA-AN-A0FT	BRCA	TCGA	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation altering degron motif	0.7199
p.S695Y	NCI-H345	lung	COSMIC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation altering degron motif	0.712
p.P493S	DO222395	MELA	ICGC	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation altering degron motif	0.6752
p.R700I	TCGA-D1-A17Q	UCEC	TCGA	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation blocking phosphorylation signal	0.6389
p.P700H	DO222517	BTCA	ICGC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation blocking phosphorylation signal	0.6389
p.T702I	LS-411N	large intestine	COSMIC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation blocking phosphorylation signal	0.5833
p.P497S	ACH-000987	Skin Cancer	CCLE	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation altering degron motif	0.5641
p.P497S	Mewo	skin	COSMIC	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation altering degron motif	0.5641
p.S704F	DO220239	SARC	ICGC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation blocking phosphorylation signal	0.5278
p.P704S	SIDM00140	Melanoma	GDSC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation blocking phosphorylation signal	0.5278
p.P704S	COLO-792	skin	COSMIC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation blocking phosphorylation signal	0.5278
p.K507N	ACH-000996	Endometrial/Uterine Cancer	CCLE	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation blocking ubiquitination signal	0.5
p.N492I	TCGA-EO-A3KX	UCEC	TCGA	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation rewiring degron network	0.3056
p.Q690H	DO234199	ESAD	ICGC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.3056
p.Q690H	DO15390	HNSC	ICGC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.3056
p.V696F	DO229028	LICA	ICGC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.3056
p.P492S	DO37839	SKCM	ICGC	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation rewiring degron network	0.3056

Showing 1 to 20 of 50 entries

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No resistance data available for this Degron.

Kaplan plot for ZEB1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZEB1

UniProt ID: P37275

Entrez ID: 6935

Protein name: Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for ZEB1 in