DegronMD - P37275(ZEB1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K494R	TCGA-50-5049	LUAD	TCGA	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation altering degron motif	0.7237
p.L486H	TCGA-66-2734	LUSC	TCGA	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation rewiring degron network	0.1389
p.P688T	TCGA-86-A456	LUAD	TCGA	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.25
p.K683N	TCGA-A5-A2K5	UCEC	TCGA	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.1111
p.G693E	TCGA-AN-A0FT	BRCA	TCGA	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation altering degron motif	0.7199
p.T703A	TCGA-B5-A11E	UCEC	TCGA	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.1111
p.T501A	TCGA-BR-8680	STAD	TCGA	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation rewiring degron network	0.2222
p.R700I	TCGA-D1-A17Q	UCEC	TCGA	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation blocking phosphorylation signal	0.6389
p.P681S	TCGA-D9-A3Z1	SKCM	TCGA	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.0556
p.S687F	TCGA-EE-A2A2	SKCM	TCGA	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.2222
p.A500T	TCGA-EI-7002	READ	TCGA	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation rewiring degron network	0.25
p.K505Q	TCGA-EO-A22U	UCEC	TCGA	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation rewiring degron network	0.1111
p.N492I	TCGA-EO-A3KX	UCEC	TCGA	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation rewiring degron network	0.3056
p.S503R	TCGA-EY-A1GI	UCEC	TCGA	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation rewiring degron network	0.1667
p.P495H	DO48583	BLCA	ICGC	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation altering degron motif	0.7694
p.P700H	DO222517	BTCA	ICGC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation blocking phosphorylation signal	0.6389
p.Q690H	DO234199	ESAD	ICGC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.3056
p.Q690H	DO15390	HNSC	ICGC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.3056
p.V696F	DO229028	LICA	ICGC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.3056
p.P488H	DO230998	LUSC	ICGC	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation rewiring degron network	0.1944
p.P488H	DO224576	LUSC	ICGC	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation rewiring degron network	0.1944
p.Q490K	DO27715	LUSC	ICGC	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation rewiring degron network	0.25
p.C705F	DO26635	LUSC	ICGC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.0556
p.P493S	DO222395	MELA	ICGC	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation altering degron motif	0.6752
p.S704F	DO220239	SARC	ICGC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation blocking phosphorylation signal	0.5278
p.P492S	DO37839	SKCM	ICGC	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation rewiring degron network	0.3056
p.Q690K	DO37431	SKCM	ICGC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.3056
p.S695F	DO51276	SKCM	ICGC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation altering degron motif	0.7982
p.S683P	DO51761	STAD	ICGC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.1111
p.P502A	DO223284	UCEC	ICGC	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation rewiring degron network	0.1944
p.P498S	SIDM00545	Melanoma	GDSC	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation rewiring degron network	0.3056
p.P498S	Mewo	skin	COSMIC	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation rewiring degron network	0.3056
p.S506N	SIDM00498	Colorectal Carcinoma	GDSC	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation rewiring degron network	0.0833
p.S506N	SNU-C5	large intestine	COSMIC	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation rewiring degron network	0.0833
p.P704S	SIDM00140	Melanoma	GDSC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation blocking phosphorylation signal	0.5278
p.P704S	COLO-792	skin	COSMIC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation blocking phosphorylation signal	0.5278
p.P703S	ACH-000968	Skin Cancer	CCLE	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.1111
p.P703S	COLO-792	skin	COSMIC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.1111
p.S505N	ACH-000970	Colon/Colorectal Cancer	CCLE	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation rewiring degron network	0.1111
p.S505N	SNU-C5	large intestine	COSMIC	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation rewiring degron network	0.1111
p.P497S	ACH-000987	Skin Cancer	CCLE	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation altering degron motif	0.5641
p.P497S	Mewo	skin	COSMIC	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation altering degron motif	0.5641
p.K507N	ACH-000996	Endometrial/Uterine Cancer	CCLE	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation blocking ubiquitination signal	0.5
p.L703V	HN	upper aerodigestive tract	COSMIC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.1111
p.S485N	SNU-C5	large intestine	COSMIC	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation rewiring degron network	0.1111
p.T702I	LS-411N	large intestine	COSMIC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation blocking phosphorylation signal	0.5833
p.P687S	COLO-792	skin	COSMIC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.2222
p.S489N	SNU-C5	large intestine	COSMIC	KKENP	DEG_APCC_KENBOX_2	493:497	Mutation rewiring degron network	0.2222
p.P683S	COLO-792	skin	COSMIC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation rewiring degron network	0.1111
p.S695Y	NCI-H345	lung	COSMIC	VGSTT	DEG_SPOP_SBC_1	691:695	Mutation altering degron motif	0.712

Kaplan plot for ZEB1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZEB1

UniProt ID: P37275

Entrez ID: 6935

Protein name: Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZEB1 in