DegronMD

Uniprot ID: P37275

Source protein: Zinc finger E-box-binding homeobox 1

Source gene: ZEB1

Class: DEG_APCC_KENBOX_2

Location: 493:497

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9186

ASA_SCORE: 134.14

COIL: 0.91

CONS_SCORE: 0.3276

DSS_SCORE: 0.4452

HELIX: 0.0266

FCONS_SCORE: 1.009

RIG_SCORE: 0.6979

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K494R	TCGA-50-5049	LUAD	TCGA	KKENP	DEG_APCC_KENBOX_2	0.7237
p.L486H	TCGA-66-2734	LUSC	TCGA	KKENP	DEG_APCC_KENBOX_2	0.1389
p.T501A	TCGA-BR-8680	STAD	TCGA	KKENP	DEG_APCC_KENBOX_2	0.2222
p.A500T	TCGA-EI-7002	READ	TCGA	KKENP	DEG_APCC_KENBOX_2	0.25
p.K505Q	TCGA-EO-A22U	UCEC	TCGA	KKENP	DEG_APCC_KENBOX_2	0.1111
p.N492I	TCGA-EO-A3KX	UCEC	TCGA	KKENP	DEG_APCC_KENBOX_2	0.3056
p.S503R	TCGA-EY-A1GI	UCEC	TCGA	KKENP	DEG_APCC_KENBOX_2	0.1667
p.P495H	DO48583	BLCA	ICGC	KKENP	DEG_APCC_KENBOX_2	0.7694
p.P488H	DO230998	LUSC	ICGC	KKENP	DEG_APCC_KENBOX_2	0.1944
p.P488H	DO224576	LUSC	ICGC	KKENP	DEG_APCC_KENBOX_2	0.1944
p.Q490K	DO27715	LUSC	ICGC	KKENP	DEG_APCC_KENBOX_2	0.25
p.P493S	DO222395	MELA	ICGC	KKENP	DEG_APCC_KENBOX_2	0.6752
p.P492S	DO37839	SKCM	ICGC	KKENP	DEG_APCC_KENBOX_2	0.3056
p.P502A	DO223284	UCEC	ICGC	KKENP	DEG_APCC_KENBOX_2	0.1944
p.P498S	SIDM00545	Melanoma	GDSC	KKENP	DEG_APCC_KENBOX_2	0.3056
p.P498S	Mewo	skin	COSMIC	KKENP	DEG_APCC_KENBOX_2	0.3056
p.S506N	SIDM00498	Colorectal Carcinoma	GDSC	KKENP	DEG_APCC_KENBOX_2	0.0833
p.S506N	SNU-C5	large_intestine	COSMIC	KKENP	DEG_APCC_KENBOX_2	0.0833
p.S505N	ACH-000970	Colon/Colorectal Cancer	CCLE	KKENP	DEG_APCC_KENBOX_2	0.1111
p.S505N	SNU-C5	large_intestine	COSMIC	KKENP	DEG_APCC_KENBOX_2	0.1111
p.P497S	ACH-000987	Skin Cancer	CCLE	KKENP	DEG_APCC_KENBOX_2	0.5641
p.P497S	Mewo	skin	COSMIC	KKENP	DEG_APCC_KENBOX_2	0.5641
p.K507N	ACH-000996	Endometrial/Uterine Cancer	CCLE	KKENP	DEG_APCC_KENBOX_2	0.5
p.S485N	SNU-C5	large_intestine	COSMIC	KKENP	DEG_APCC_KENBOX_2	0.1111
p.S489N	SNU-C5	large_intestine	COSMIC	KKENP	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P37275	Zinc finger E-box-binding homeobox 1	DEG_APCC_KENBOX_2	493:497	KKENP	APC,CDC20,FZR1	0.9186	More...
P59817	Zinc finger protein 280A	DEG_APCC_KENBOX_2	268:272	KKENP	APC,CDC20,FZR1	0.6405	More...
Q86YH2	Zinc finger protein 280B	DEG_APCC_KENBOX_2	277:281	KKENP	APC,CDC20,FZR1	0.9189	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons