DegronMD - P59817(ZNF280A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L258P	TCGA-62-A46R	LUAD	TCGA	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.0556
p.L258P	DO45355	LUAD	ICGC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.0556
p.V274L	TCGA-AG-3894	READ	TCGA	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.2778
p.V274L	DO36419	READ	ICGC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.2778
p.V274M	TCGA-BR-8078	STAD	TCGA	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.2778
p.V274M	DO38288	STAD	ICGC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.2778
p.P267H	TCGA-E9-A1N8	BRCA	TCGA	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.3056
p.P267H	DO3019	BRCA	ICGC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.3056
p.P272L	TCGA-FW-A3TV	SKCM	TCGA	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation altering degron motif	0.6471
p.P272L	DO38159	SKCM	ICGC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation altering degron motif	0.6471
p.E270Q	TCGA-G2-AA3D	BLCA	TCGA	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation altering degron motif	0.6744
p.E270Q	DO51884	BLCA	ICGC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation altering degron motif	0.6744
p.K268N	TCGA-ND-A4WC	UCS	TCGA	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation altering degron motif	0.5806
p.N278D	DO228483	BRCA	ICGC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1667
p.N278D	DO229010	COCA	ICGC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1667
p.N278D	DO229013	COCA	ICGC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1667
p.N278D	DO229016	COCA	ICGC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1667
p.N278D	DO229003	COCA	ICGC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1667
p.N278D	DO229346	LAML	ICGC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1667
p.N278D	DO229473	LAML	ICGC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1667
p.N278D	DO230659	LAML	ICGC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1667
p.N278D	DO231140	LAML	ICGC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1667
p.F279V	DO227634	COCA	ICGC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1389
p.L276F	DO234169	ESAD	ICGC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.2222
p.L276F	SIDM00845	Burkitt's Lymphoma	GDSC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.2222
p.L276F	SIDM00650	Small Cell Lung Carcinoma	GDSC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.2222
p.L276F	SIDM00844	Burkitt's Lymphoma	GDSC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.2222
p.L276F	SIDM01681	Non-Cancerous	GDSC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.2222
p.L276F	SIDM01318	Hepatocellular Carcinoma	GDSC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.2222
p.L276F	SIDM01686	Chronic Myelogenous Leukemia	GDSC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.2222
p.N262T	SIDM00530	Esophageal Carcinoma	GDSC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1667
p.N262T	SIDM00821	Kidney Carcinoma	GDSC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1667
p.N262T	ACH-001544	Esophageal Cancer	CCLE	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1667
p.N262T	KYAE-1	oesophagus	COSMIC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1667
p.S277N	SIDM01196	Hepatocellular Carcinoma	GDSC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1944
p.S277N	ACH-000422	Liver Cancer	CCLE	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1944
p.S277N	SNU-475	liver	COSMIC	KKENP	DEG_APCC_KENBOX_2	268:272	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF280A

UniProt ID: P59817

Entrez ID: 129025

Protein name: Zinc finger protein 280A (3'OY11.1) (Suppressor of hairy wing homolog 1) (Zinc finger protein 636)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF280A in