DegronMD

Uniprot ID: P59817

Source protein: Zinc finger protein 280A

Source gene: ZNF280A

Class: DEG_APCC_KENBOX_2

Location: 268:272

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6405

ASA_SCORE: 102.84

COIL: 0.6062

CONS_SCORE: 0.3967

DSS_SCORE: 0.3892

HELIX: 0.0324

FCONS_SCORE: 1.011

RIG_SCORE: 0.7362

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L258P	TCGA-62-A46R	LUAD	TCGA	KKENP	DEG_APCC_KENBOX_2	0.0556
p.L258P	DO45355	LUAD	ICGC	KKENP	DEG_APCC_KENBOX_2	0.0556
p.V274L	TCGA-AG-3894	READ	TCGA	KKENP	DEG_APCC_KENBOX_2	0.2778
p.V274L	DO36419	READ	ICGC	KKENP	DEG_APCC_KENBOX_2	0.2778
p.V274M	TCGA-BR-8078	STAD	TCGA	KKENP	DEG_APCC_KENBOX_2	0.2778
p.V274M	DO38288	STAD	ICGC	KKENP	DEG_APCC_KENBOX_2	0.2778
p.P267H	TCGA-E9-A1N8	BRCA	TCGA	KKENP	DEG_APCC_KENBOX_2	0.3056
p.P267H	DO3019	BRCA	ICGC	KKENP	DEG_APCC_KENBOX_2	0.3056
p.P272L	TCGA-FW-A3TV	SKCM	TCGA	KKENP	DEG_APCC_KENBOX_2	0.6471
p.P272L	DO38159	SKCM	ICGC	KKENP	DEG_APCC_KENBOX_2	0.6471
p.E270Q	TCGA-G2-AA3D	BLCA	TCGA	KKENP	DEG_APCC_KENBOX_2	0.6744
p.E270Q	DO51884	BLCA	ICGC	KKENP	DEG_APCC_KENBOX_2	0.6744
p.K268N	TCGA-ND-A4WC	UCS	TCGA	KKENP	DEG_APCC_KENBOX_2	0.5806
p.N278D	DO228483	BRCA	ICGC	KKENP	DEG_APCC_KENBOX_2	0.1667
p.N278D	DO229010	COCA	ICGC	KKENP	DEG_APCC_KENBOX_2	0.1667
p.N278D	DO229013	COCA	ICGC	KKENP	DEG_APCC_KENBOX_2	0.1667
p.N278D	DO229016	COCA	ICGC	KKENP	DEG_APCC_KENBOX_2	0.1667
p.N278D	DO229003	COCA	ICGC	KKENP	DEG_APCC_KENBOX_2	0.1667
p.N278D	DO229346	LAML	ICGC	KKENP	DEG_APCC_KENBOX_2	0.1667
p.N278D	DO229473	LAML	ICGC	KKENP	DEG_APCC_KENBOX_2	0.1667
p.N278D	DO230659	LAML	ICGC	KKENP	DEG_APCC_KENBOX_2	0.1667
p.N278D	DO231140	LAML	ICGC	KKENP	DEG_APCC_KENBOX_2	0.1667
p.F279V	DO227634	COCA	ICGC	KKENP	DEG_APCC_KENBOX_2	0.1389
p.L276F	DO234169	ESAD	ICGC	KKENP	DEG_APCC_KENBOX_2	0.2222
p.L276F	SIDM00845	Burkitt's Lymphoma	GDSC	KKENP	DEG_APCC_KENBOX_2	0.2222
p.L276F	SIDM00650	Small Cell Lung Carcinoma	GDSC	KKENP	DEG_APCC_KENBOX_2	0.2222
p.L276F	SIDM00844	Burkitt's Lymphoma	GDSC	KKENP	DEG_APCC_KENBOX_2	0.2222
p.L276F	SIDM01681	Non-Cancerous	GDSC	KKENP	DEG_APCC_KENBOX_2	0.2222
p.L276F	SIDM01318	Hepatocellular Carcinoma	GDSC	KKENP	DEG_APCC_KENBOX_2	0.2222
p.L276F	SIDM01686	Chronic Myelogenous Leukemia	GDSC	KKENP	DEG_APCC_KENBOX_2	0.2222
p.N262T	SIDM00530	Esophageal Carcinoma	GDSC	KKENP	DEG_APCC_KENBOX_2	0.1667
p.N262T	SIDM00821	Kidney Carcinoma	GDSC	KKENP	DEG_APCC_KENBOX_2	0.1667
p.N262T	ACH-001544	Esophageal Cancer	CCLE	KKENP	DEG_APCC_KENBOX_2	0.1667
p.N262T	KYAE-1	oesophagus	COSMIC	KKENP	DEG_APCC_KENBOX_2	0.1667
p.S277N	SIDM01196	Hepatocellular Carcinoma	GDSC	KKENP	DEG_APCC_KENBOX_2	0.1944
p.S277N	ACH-000422	Liver Cancer	CCLE	KKENP	DEG_APCC_KENBOX_2	0.1944
p.S277N	SNU-475	liver	COSMIC	KKENP	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P37275	Zinc finger E-box-binding homeobox 1	DEG_APCC_KENBOX_2	493:497	KKENP	APC,CDC20,FZR1	0.9186	More...
P59817	Zinc finger protein 280A	DEG_APCC_KENBOX_2	268:272	KKENP	APC,CDC20,FZR1	0.6405	More...
Q86YH2	Zinc finger protein 280B	DEG_APCC_KENBOX_2	277:281	KKENP	APC,CDC20,FZR1	0.9189	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KKENP

Degron related mutations and impact score

Drug responses associated with ZNF280A mutations

All proteins holding degron of KKENP