DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
KKENP
Uniprot ID:
Q86YH2
Source protein:
Zinc finger protein 280B
Source gene:
ZNF280B
Class:
DEG_APCC_KENBOX_2
Location:
277:281
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9189
ASA_SCORE:
102.02
COIL:
0.7022
CONS_SCORE:
0.3516
DSS_SCORE:
0.3785
HELIX:
0.041
FCONS_SCORE:
0.927
RIG_SCORE:
0.7468
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.N280S
TCGA-BR-8680
STAD
TCGA
KKENP
DEG_APCC_KENBOX_2
0.7069
p.N280S
DO47769
STAD
ICGC
KKENP
DEG_APCC_KENBOX_2
0.7069
p.P281L
TCGA-DD-AAVX
LIHC
TCGA
KKENP
DEG_APCC_KENBOX_2
0.6471
p.P281L
DO52283
LIHC
ICGC
KKENP
DEG_APCC_KENBOX_2
0.6471
p.G291R
TCGA-XY-A8S2
TGCT
TCGA
KKENP
DEG_APCC_KENBOX_2
0.0556
p.D275E
SIDM01624
Bladder Carcinoma
GDSC
KKENP
DEG_APCC_KENBOX_2
0.2778
p.D275E
SIDM01529
Bladder Carcinoma
GDSC
KKENP
DEG_APCC_KENBOX_2
0.2778
p.D275E
ACH-000011
Bladder Cancer
CCLE
KKENP
DEG_APCC_KENBOX_2
0.2778
p.D275E
ACH-000026
Bladder Cancer
CCLE
KKENP
DEG_APCC_KENBOX_2
0.2778
Drug responses associated with ZNF280B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KKENP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P37275
Zinc finger E-box-binding homeobox 1
DEG_APCC_KENBOX_2
493:497
KKENP
APC,CDC20,FZR1
0.9186
More...
P59817
Zinc finger protein 280A
DEG_APCC_KENBOX_2
268:272
KKENP
APC,CDC20,FZR1
0.6405
More...
Q86YH2
Zinc finger protein 280B
DEG_APCC_KENBOX_2
277:281
KKENP
APC,CDC20,FZR1
0.9189
More...