DegronMD

Uniprot ID: Q86YH2

Source protein: Zinc finger protein 280B

Source gene: ZNF280B

Class: DEG_APCC_KENBOX_2

Location: 277:281

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9189

ASA_SCORE: 102.02

COIL: 0.7022

CONS_SCORE: 0.3516

DSS_SCORE: 0.3785

HELIX: 0.041

FCONS_SCORE: 0.927

RIG_SCORE: 0.7468

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N280S	TCGA-BR-8680	STAD	TCGA	KKENP	DEG_APCC_KENBOX_2	0.7069
p.N280S	DO47769	STAD	ICGC	KKENP	DEG_APCC_KENBOX_2	0.7069
p.P281L	TCGA-DD-AAVX	LIHC	TCGA	KKENP	DEG_APCC_KENBOX_2	0.6471
p.P281L	DO52283	LIHC	ICGC	KKENP	DEG_APCC_KENBOX_2	0.6471
p.D275E	SIDM01624	Bladder Carcinoma	GDSC	KKENP	DEG_APCC_KENBOX_2	0.2778
p.D275E	SIDM01529	Bladder Carcinoma	GDSC	KKENP	DEG_APCC_KENBOX_2	0.2778
p.D275E	ACH-000011	Bladder Cancer	CCLE	KKENP	DEG_APCC_KENBOX_2	0.2778
p.D275E	ACH-000026	Bladder Cancer	CCLE	KKENP	DEG_APCC_KENBOX_2	0.2778
p.G291R	TCGA-XY-A8S2	TGCT	TCGA	KKENP	DEG_APCC_KENBOX_2	0.0556

Showing 1 to 9 of 9 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P37275	Zinc finger E-box-binding homeobox 1	DEG_APCC_KENBOX_2	493:497	KKENP	APC,CDC20,FZR1	0.9186	More...
P59817	Zinc finger protein 280A	DEG_APCC_KENBOX_2	268:272	KKENP	APC,CDC20,FZR1	0.6405	More...
Q86YH2	Zinc finger protein 280B	DEG_APCC_KENBOX_2	277:281	KKENP	APC,CDC20,FZR1	0.9189	More...

Showing 1 to 3 of 3 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons