DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
VGSTT
Uniprot ID:
P98088
Source protein:
Mucin-5AC
Source gene:
MUC5AC
Class:
DEG_SPOP_SBC_1
Location:
5117:5121
E3 ligase:
SPOP
DEGRON score:
0.987
ASA_SCORE:
80.3
COIL:
0.924
CONS_SCORE:
0
DSS_SCORE:
0.6082
HELIX:
0.021
FCONS_SCORE:
0
RIG_SCORE:
0.6443
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G5113V
SIDM00646
Small Cell Lung Carcinoma
GDSC
VGSTT
DEG_SPOP_SBC_1
0.2222
p.P5109S
SIDM00261
Ewing's Sarcoma
GDSC
VGSTT
DEG_SPOP_SBC_1
0.1111
Drug responses associated with MUC5AC mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VGSTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A8CG34
Nuclear envelope pore membrane protein POM 121C
DEG_SPOP_SBC_1
1145:1149
VGSTT
SPOP
0.989
More...
P37275
Zinc finger E-box-binding homeobox 1
DEG_SPOP_SBC_1
691:695
VGSTT
SPOP
0.9133
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
5117:5121
VGSTT
SPOP
0.987
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
5127:5131
VGSTT
SPOP
0.9091
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
2508:2512
VGSTT
SPOP
0.8332
More...
Q9UQ52
Contactin-6
DEG_SPOP_SBC_1
743:747
VGSTT
SPOP
0.8232
More...
A6NF01
Putative nuclear envelope pore membrane protein POM 121B
DEG_SPOP_SBC_1
750:754
VGSTT
SPOP
0.9976
More...