DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 2508:2512

E3 ligase: SPOP

DEGRON score: 0.8332

ASA_SCORE: 72.94

COIL: 0.6534

CONS_SCORE: 0

DSS_SCORE: 0.4319

HELIX: 0.011

FCONS_SCORE: 0

RIG_SCORE: 0.7336

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2502S	TCGA-06-5416	GBM	TCGA	VGSTT	DEG_SPOP_SBC_1	0.1667
p.P2502S	DO10880	GBM	ICGC	VGSTT	DEG_SPOP_SBC_1	0.1667
p.P2502S	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	VGSTT	DEG_SPOP_SBC_1	0.1667
p.S2507N	TCGA-D1-A17H	UCEC	TCGA	VGSTT	DEG_SPOP_SBC_1	0.3056
p.S2507N	DO41847	UCEC	ICGC	VGSTT	DEG_SPOP_SBC_1	0.3056
p.S2498Y	TCGA-D3-A2JC	SKCM	TCGA	VGSTT	DEG_SPOP_SBC_1	0.0556
p.S2498Y	DO229025	LICA	ICGC	VGSTT	DEG_SPOP_SBC_1	0.0556
p.S2498Y	DO47578	SKCM	ICGC	VGSTT	DEG_SPOP_SBC_1	0.0556
p.G2509C	TCGA-DM-A1HB	COAD	TCGA	VGSTT	DEG_SPOP_SBC_1	0.6489
p.K2521N	TCGA-E6-A1LX	UCEC	TCGA	VGSTT	DEG_SPOP_SBC_1	0.1944
p.K2521N	DO41020	UCEC	ICGC	VGSTT	DEG_SPOP_SBC_1	0.1944
p.P2500Q	TCGA-E8-A2EA	THCA	TCGA	VGSTT	DEG_SPOP_SBC_1	0.1111
p.P2500Q	DO38926	THCA	ICGC	VGSTT	DEG_SPOP_SBC_1	0.1111
p.L2520F	TCGA-EE-A3AC	SKCM	TCGA	VGSTT	DEG_SPOP_SBC_1	0.1111
p.L2520F	DO37631	SKCM	ICGC	VGSTT	DEG_SPOP_SBC_1	0.1111
p.G2518S	TCGA-FW-A3R5	SKCM	TCGA	VGSTT	DEG_SPOP_SBC_1	0.1667
p.G2518S	DO37406	SKCM	ICGC	VGSTT	DEG_SPOP_SBC_1	0.1667
p.M2517I	TCGA-GN-A266	SKCM	TCGA	VGSTT	DEG_SPOP_SBC_1	0.1944
p.M2517I	DO222749	MELA	ICGC	VGSTT	DEG_SPOP_SBC_1	0.1944
p.M2517I	DO37432	SKCM	ICGC	VGSTT	DEG_SPOP_SBC_1	0.1944
p.T2506A	DO48361	BLCA	ICGC	VGSTT	DEG_SPOP_SBC_1	0.2778
p.T2506A	DO229010	COCA	ICGC	VGSTT	DEG_SPOP_SBC_1	0.2778
p.T2506A	DO229016	COCA	ICGC	VGSTT	DEG_SPOP_SBC_1	0.2778
p.T2506A	DO229003	COCA	ICGC	VGSTT	DEG_SPOP_SBC_1	0.2778
p.T2506A	DO229005	COCA	ICGC	VGSTT	DEG_SPOP_SBC_1	0.2778
p.T2506A	DO234285	ESAD	ICGC	VGSTT	DEG_SPOP_SBC_1	0.2778
p.T2506A	DO230942	LUSC	ICGC	VGSTT	DEG_SPOP_SBC_1	0.2778
p.T2506A	DO52365	LUSC	ICGC	VGSTT	DEG_SPOP_SBC_1	0.2778
p.T2522K	DO228976	LICA	ICGC	VGSTT	DEG_SPOP_SBC_1	0.0556
p.T2511N	DO229006	LICA	ICGC	VGSTT	DEG_SPOP_SBC_1	0.7055
p.S2498C	DO231467	THCA	ICGC	VGSTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	1145:1149	VGSTT	SPOP	0.989	More...
P37275	Zinc finger E-box-binding homeobox 1	DEG_SPOP_SBC_1	691:695	VGSTT	SPOP	0.9133	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	5117:5121	VGSTT	SPOP	0.987	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	5127:5131	VGSTT	SPOP	0.9091	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2508:2512	VGSTT	SPOP	0.8332	More...
Q9UQ52	Contactin-6	DEG_SPOP_SBC_1	743:747	VGSTT	SPOP	0.8232	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	750:754	VGSTT	SPOP	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VGSTT

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of VGSTT