DegronMD

Uniprot ID: P98088

Source protein: Mucin-5AC

Source gene: MUC5AC

Class: DEG_SPOP_SBC_1

Location: 5127:5131

E3 ligase: SPOP

DEGRON score: 0.9091

ASA_SCORE: 81.78

COIL: 0.9388

CONS_SCORE: 0

DSS_SCORE: 0.5911

HELIX: 0.0146

FCONS_SCORE: 0

RIG_SCORE: 0.682

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V5132I	SIDM00932	Kidney Carcinoma	GDSC	VGSTT	DEG_SPOP_SBC_1	0.3056
p.V5132I	CAL-54	kidney	COSMIC	VGSTT	DEG_SPOP_SBC_1	0.3056
p.T5130A	SIDM00498	Colorectal Carcinoma	GDSC	VGSTT	DEG_SPOP_SBC_1	0.7139
p.T5130A	SNU-C5	large_intestine	COSMIC	VGSTT	DEG_SPOP_SBC_1	0.7139
p.G5133R	SIDM00018	Acute Myeloid Leukemia	GDSC	VGSTT	DEG_SPOP_SBC_1	0.2778
p.G5133R	KO52	haematopoietic_and_lymphoid_tissue	COSMIC	VGSTT	DEG_SPOP_SBC_1	0.2778
p.P5140L	SIDM01706	Hodgkin's Lymphoma	GDSC	VGSTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	1145:1149	VGSTT	SPOP	0.989	More...
P37275	Zinc finger E-box-binding homeobox 1	DEG_SPOP_SBC_1	691:695	VGSTT	SPOP	0.9133	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	5117:5121	VGSTT	SPOP	0.987	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	5127:5131	VGSTT	SPOP	0.9091	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2508:2512	VGSTT	SPOP	0.8332	More...
Q9UQ52	Contactin-6	DEG_SPOP_SBC_1	743:747	VGSTT	SPOP	0.8232	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	750:754	VGSTT	SPOP	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons