DegronMD

Uniprot ID: A8CG34

Source protein: Nuclear envelope pore membrane protein POM 121C

Source gene: POM121C

Class: DEG_SCF_FBW7_1

Location: 539:546

E3 ligase: FBXW7

DEGRON score: 0.9558

ASA_SCORE: 94.925

COIL: 0.9469

CONS_SCORE: 0.5951

DSS_SCORE: 0.6193

HELIX: 0.0195

FCONS_SCORE: 0.9234

RIG_SCORE: 0.6384

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S536L	DO231075	LUSC	ICGC	VTETPPTT	DEG_SCF_FBW7_1	0.25
p.A556T	DO220876	MELA	ICGC	VTETPPTT	DEG_SCF_FBW7_1	0.0556
p.P555S	DO41542	UCEC	ICGC	VTETPPTT	DEG_SCF_FBW7_1	0.0833
p.A534D	DO42673	UCEC	ICGC	VTETPPTT	DEG_SCF_FBW7_1	0.1944
p.E541G	ACH-000141	Gallbladder Cancer	CCLE	VTETPPTT	DEG_SCF_FBW7_1	0.6087
p.D530E	ACH-000494	Non-Cancerous	CCLE	VTETPPTT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SCF_FBW7_1	539:546	VTETPPTT	FBXW7	0.9558	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons