DegronMD

Uniprot ID: A8CG34

Source protein: Nuclear envelope pore membrane protein POM 121C

Source gene: POM121C

Class: DEG_SCF_FBW7_1

Location: 1095:1101

E3 ligase: FBXW7

DEGRON score: 0.9889

ASA_SCORE: 75.8286

COIL: 0.947

CONS_SCORE: 0.5567

DSS_SCORE: 0.3473

HELIX: 0.0186

FCONS_SCORE: 0.8385

RIG_SCORE: 0.6925

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1092W	DO51551	KIRP	ICGC	VATPGSS	DEG_SCF_FBW7_1	0.25
p.S1090R	DO229026	LICA	ICGC	VATPGSS	DEG_SCF_FBW7_1	0.1944
p.T1104I	DO37986	SKCM	ICGC	VATPGSS	DEG_SCF_FBW7_1	0.25
p.P1085L	ACH-000331	Lung Cancer	CCLE	VATPGSS	DEG_SCF_FBW7_1	0.0556
p.S1108G	ACH-000988	Endometrial/Uterine Cancer	CCLE	VATPGSS	DEG_SCF_FBW7_1	0.1389
p.S1108G	MFE-319	endometrium	COSMIC	VATPGSS	DEG_SCF_FBW7_1	0.1389
p.A1106V	ES8	bone	COSMIC	VATPGSS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SCF_FBW7_1	1095:1101	VATPGSS	FBXW7	0.9889	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SCF_FBW7_1	1115:1121	VATPGSS	FBXW7	0.991	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SCF_FBW7_1	700:706	VATPGSS	FBXW7	0.9919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons