DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VATPGSS
Uniprot ID:
Q96HA1
Source protein:
Nuclear envelope pore membrane protein POM 121
Source gene:
POM121
Class:
DEG_SCF_FBW7_1
Location:
1115:1121
E3 ligase:
FBXW7
DEGRON score:
0.991
ASA_SCORE:
76.1571
COIL:
0.9554
CONS_SCORE:
0.5294
DSS_SCORE:
0.3882
HELIX:
0.0126
FCONS_SCORE:
0.8302
RIG_SCORE:
0.6853
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A1126D
DO42472
UCEC
ICGC
VATPGSS
DEG_SCF_FBW7_1
0.1944
p.P1105L
SK-MEL-24
skin
COSMIC
VATPGSS
DEG_SCF_FBW7_1
0.0556
Drug responses associated with POM121 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VATPGSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A8CG34
Nuclear envelope pore membrane protein POM 121C
DEG_SCF_FBW7_1
1095:1101
VATPGSS
FBXW7
0.9889
More...
Q96HA1
Nuclear envelope pore membrane protein POM 121
DEG_SCF_FBW7_1
1115:1121
VATPGSS
FBXW7
0.991
More...
A6NF01
Putative nuclear envelope pore membrane protein POM 121B
DEG_SCF_FBW7_1
700:706
VATPGSS
FBXW7
0.9919
More...