DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
VATPGSS
Uniprot ID:
A6NF01
Source protein:
Putative nuclear envelope pore membrane protein POM 121B
Source gene:
POM121B
Class:
DEG_SCF_FBW7_1
Location:
700:706
E3 ligase:
FBXW7
DEGRON score:
0.9919
ASA_SCORE:
70.9
COIL:
0.9349
CONS_SCORE:
0.1805
DSS_SCORE:
0.3418
HELIX:
0.0219
FCONS_SCORE:
0.5464
RIG_SCORE:
0.6944
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with POM121B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VATPGSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A8CG34
Nuclear envelope pore membrane protein POM 121C
DEG_SCF_FBW7_1
1095:1101
VATPGSS
FBXW7
0.9889
More...
Q96HA1
Nuclear envelope pore membrane protein POM 121
DEG_SCF_FBW7_1
1115:1121
VATPGSS
FBXW7
0.991
More...
A6NF01
Putative nuclear envelope pore membrane protein POM 121B
DEG_SCF_FBW7_1
700:706
VATPGSS
FBXW7
0.9919
More...