DegronMD

Uniprot ID: A8CG34

Source protein: Nuclear envelope pore membrane protein POM 121C

Source gene: POM121C

Class: DEG_SCF_SKP2-CKS1_1

Location: 458:465

E3 ligase: SKP2,CSK1

DEGRON score: 0.5453

ASA_SCORE: 94.55

COIL: 0.8878

CONS_SCORE: 0.5773

DSS_SCORE: 0.8194

HELIX: 0.0924

FCONS_SCORE: 0.8785

RIG_SCORE: 0.623

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P448L	TCGA-EE-A2MS	SKCM	TCGA	AADTTPRK	DEG_SCF_SKP2-CKS1_1	0.0556
p.S453F	DO222450	ESCA	ICGC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	0.6389
p.A448V	DO41235	UCEC	ICGC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	0.0556
p.K472T	SIDM01126	Small Cell Lung Carcinoma	GDSC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	0.1389
p.K472T	SIDM00694	Other Solid Cancers	GDSC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	0.1389
p.K472T	SIDM00954	Breast Carcinoma	GDSC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	0.1389
p.K472T	HUTU-80	small_intestine	COSMIC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	0.1389
p.P470S	COLO-792	skin	COSMIC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SCF_SKP2-CKS1_1	458:465	AADTTPRK	SKP2,CSK1	0.5453	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SCF_SKP2-CKS1_1	481:488	AADTTPRK	SKP2,CSK1	0.7141	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SCF_SKP2-CKS1_1	65:72	AADTTPRK	SKP2,CSK1	0.8757	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons