DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
AADTTPRK
Uniprot ID:
A6NF01
Source protein:
Putative nuclear envelope pore membrane protein POM 121B
Source gene:
POM121B
Class:
DEG_SCF_SKP2-CKS1_1
Location:
65:72
E3 ligase:
SKP2,CSK1
DEGRON score:
0.8757
ASA_SCORE:
96.5
COIL:
0.9111
CONS_SCORE:
0.1775
DSS_SCORE:
0.8224
HELIX:
0.0586
FCONS_SCORE:
0.5678
RIG_SCORE:
0.6225
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with POM121B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AADTTPRK
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A8CG34
Nuclear envelope pore membrane protein POM 121C
DEG_SCF_SKP2-CKS1_1
458:465
AADTTPRK
SKP2,CSK1
0.5453
More...
Q96HA1
Nuclear envelope pore membrane protein POM 121
DEG_SCF_SKP2-CKS1_1
481:488
AADTTPRK
SKP2,CSK1
0.7141
More...
A6NF01
Putative nuclear envelope pore membrane protein POM 121B
DEG_SCF_SKP2-CKS1_1
65:72
AADTTPRK
SKP2,CSK1
0.8757
More...