DegronMD - Q5RL73(RBM48)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R277G	TCGA-05-4410	LUAD	TCGA	AITSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.0833
p.R277G	DO25426	LUAD	ICGC	AITSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.0833
p.P314Q	TCGA-09-2044	OV	TCGA	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.1944
p.P314Q	DO28923	OV	ICGC	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.1944
p.A330V	TCGA-19-5956	GBM	TCGA	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.1667
p.A330V	TCGA-AX-A0J1	UCEC	TCGA	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.1667
p.A330V	TCGA-B5-A3FC	UCEC	TCGA	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.1667
p.A330V	DO13863	GBM	ICGC	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.1667
p.A330V	DO41871	UCEC	ICGC	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.1667
p.A330V	DO41199	UCEC	ICGC	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.1667
p.R334W	TCGA-A5-A0G1	UCEC	TCGA	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.0556
p.R334W	TCGA-AG-A002	READ	TCGA	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.0556
p.R334W	TCGA-EO-A3B0	UCEC	TCGA	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.0556
p.R334W	TCGA-FI-A2D5	UCEC	TCGA	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.0556
p.R334W	DO219773	UCEC	ICGC	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.0556
p.R334W	DO42472	UCEC	ICGC	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.0556
p.R334W	DO41331	UCEC	ICGC	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.0556
p.R334W	SIDM01611	Endometrial Carcinoma	GDSC	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.0556
p.R334W	ACH-000996	Endometrial/Uterine Cancer	CCLE	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.0556
p.A270V	TCGA-AX-A1CE	UCEC	TCGA	AITSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.2778
p.A270V	DO42280	UCEC	ICGC	AITSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.2778
p.R334Q	TCGA-AX-A1CE	UCEC	TCGA	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.0556
p.R334Q	DO42280	UCEC	ICGC	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.0556
p.R273S	TCGA-D3-A5GT	SKCM	TCGA	AITSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1944
p.R273S	DO47677	SKCM	ICGC	AITSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1944
p.G260D	TCGA-DU-6407	LGG	TCGA	AITSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.2222
p.G260D	DO22295	LGG	ICGC	AITSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.2222
p.R334L	TCGA-EE-A184	SKCM	TCGA	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.0556
p.R334L	DO47442	SKCM	ICGC	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.0556
p.P259H	TCGA-EE-A29L	SKCM	TCGA	AITSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1944
p.P259H	TCGA-FS-A1Z0	SKCM	TCGA	AITSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1944
p.P259H	DO37835	SKCM	ICGC	AITSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1944
p.P259H	DO37431	SKCM	ICGC	AITSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1944
p.L312M	TCGA-EE-A2GT	SKCM	TCGA	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.1389
p.L312M	DO37946	SKCM	ICGC	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.1389
p.D323N	TCGA-EY-A1G8	UCEC	TCGA	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation altering degron motif	0.5821
p.D323N	DO234339	ESAD	ICGC	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation altering degron motif	0.5821
p.D323N	DO43578	UCEC	ICGC	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation altering degron motif	0.5821
p.N254T	TCGA-IN-A6RL	STAD	TCGA	AITSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.0556
p.N254T	DO51738	STAD	ICGC	AITSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.0556
p.S268L	TCGA-XF-A9SM	BLCA	TCGA	AITSS	DEG_SPOP_SBC_1	264:268	Mutation altering degron motif	0.7667
p.S268L	DO223597	BLCA	ICGC	AITSS	DEG_SPOP_SBC_1	264:268	Mutation altering degron motif	0.7667
p.A264V	DO233179	GACA	ICGC	AITSS	DEG_SPOP_SBC_1	264:268	Mutation altering degron motif	0.5825
p.L326F	DO228974	LICA	ICGC	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.2778
p.A257V	SIDM02026	Colorectal Carcinoma	GDSC	AITSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1389
p.T278S	SIDM00777	Colorectal Carcinoma	GDSC	AITSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.0556
p.T278S	ACH-000360	Colon/Colorectal Cancer	CCLE	AITSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.0556
p.T278S	NCI-H508	large intestine	COSMIC	AITSS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.0556
p.T329M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.1944
p.T329M	ACH-002256	Leukemia	CCLE	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.1944
p.T329M	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VDMHDD	LIG_APCC_ABBA_1	319:324	Mutation rewiring degron network	0.1944
p.T266A	SIDM00498	Colorectal Carcinoma	GDSC	AITSS	DEG_SPOP_SBC_1	264:268	Mutation altering degron motif	0.7139
p.T266A	ACH-000970	Colon/Colorectal Cancer	CCLE	AITSS	DEG_SPOP_SBC_1	264:268	Mutation altering degron motif	0.7139
p.T266A	SNU-C5	large intestine	COSMIC	AITSS	DEG_SPOP_SBC_1	264:268	Mutation altering degron motif	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBM48

UniProt ID: Q5RL73

Entrez ID: 84060

Protein name: RNA-binding protein 48

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBM48 in