DegronMD

Uniprot ID: Q5RL73

Source protein: RNA-binding protein 48

Source gene: RBM48

Class: DEG_SPOP_SBC_1

Location: 264:268

E3 ligase: SPOP

DEGRON score: 0.6026

ASA_SCORE: 64.92

COIL: 0.7766

CONS_SCORE: 0.3895

DSS_SCORE: 0.4712

HELIX: 0.1506

FCONS_SCORE: 0.9323

RIG_SCORE: 0.705

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R277G	TCGA-05-4410	LUAD	TCGA	AITSS	DEG_SPOP_SBC_1	0.0833
p.R277G	DO25426	LUAD	ICGC	AITSS	DEG_SPOP_SBC_1	0.0833
p.A270V	TCGA-AX-A1CE	UCEC	TCGA	AITSS	DEG_SPOP_SBC_1	0.2778
p.A270V	DO42280	UCEC	ICGC	AITSS	DEG_SPOP_SBC_1	0.2778
p.R273S	TCGA-D3-A5GT	SKCM	TCGA	AITSS	DEG_SPOP_SBC_1	0.1944
p.R273S	DO47677	SKCM	ICGC	AITSS	DEG_SPOP_SBC_1	0.1944
p.G260D	TCGA-DU-6407	LGG	TCGA	AITSS	DEG_SPOP_SBC_1	0.2222
p.G260D	DO22295	LGG	ICGC	AITSS	DEG_SPOP_SBC_1	0.2222
p.P259H	TCGA-EE-A29L	SKCM	TCGA	AITSS	DEG_SPOP_SBC_1	0.1944
p.P259H	TCGA-FS-A1Z0	SKCM	TCGA	AITSS	DEG_SPOP_SBC_1	0.1944
p.P259H	DO37835	SKCM	ICGC	AITSS	DEG_SPOP_SBC_1	0.1944
p.P259H	DO37431	SKCM	ICGC	AITSS	DEG_SPOP_SBC_1	0.1944
p.N254T	TCGA-IN-A6RL	STAD	TCGA	AITSS	DEG_SPOP_SBC_1	0.0556
p.N254T	DO51738	STAD	ICGC	AITSS	DEG_SPOP_SBC_1	0.0556
p.S268L	TCGA-XF-A9SM	BLCA	TCGA	AITSS	DEG_SPOP_SBC_1	0.7667
p.S268L	DO223597	BLCA	ICGC	AITSS	DEG_SPOP_SBC_1	0.7667
p.A264V	DO233179	GACA	ICGC	AITSS	DEG_SPOP_SBC_1	0.5825
p.A257V	SIDM02026	Colorectal Carcinoma	GDSC	AITSS	DEG_SPOP_SBC_1	0.1389
p.T278S	SIDM00777	Colorectal Carcinoma	GDSC	AITSS	DEG_SPOP_SBC_1	0.0556
p.T278S	ACH-000360	Colon/Colorectal Cancer	CCLE	AITSS	DEG_SPOP_SBC_1	0.0556
p.T278S	NCI-H508	large_intestine	COSMIC	AITSS	DEG_SPOP_SBC_1	0.0556
p.T266A	SIDM00498	Colorectal Carcinoma	GDSC	AITSS	DEG_SPOP_SBC_1	0.7139
p.T266A	ACH-000970	Colon/Colorectal Cancer	CCLE	AITSS	DEG_SPOP_SBC_1	0.7139
p.T266A	SNU-C5	large_intestine	COSMIC	AITSS	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	389:393	AITSS	SPOP	0.9987	More...
Q5RL73	RNA-binding protein 48	DEG_SPOP_SBC_1	264:268	AITSS	SPOP	0.6026	More...
Q8N1G0	Zinc finger protein 687	DEG_SPOP_SBC_1	639:643	AITSS	SPOP	0.9699	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	412:416	AITSS	SPOP	0.9984	More...
Q9Y2F5	Little elongation complex subunit 1	DEG_SPOP_SBC_1	236:240	AITSS	SPOP	0.9901	More...
Q6ZVF9	G protein-regulated inducer of neurite outgrowth 3	DEG_SPOP_SBC_1	145:149	AITSS	SPOP	0.9606	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons