DegronMD

Uniprot ID: Q5RL73

Source protein: RNA-binding protein 48

Source gene: RBM48

Class: LIG_APCC_ABBA_1

Location: 319:324

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.521

ASA_SCORE: 86.45

COIL: 0.8152

CONS_SCORE: 0.4435

DSS_SCORE: 0.4031

HELIX: 0.1262

FCONS_SCORE: 0.9265

RIG_SCORE: 0.7743

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P314Q	TCGA-09-2044	OV	TCGA	VDMHDD	LIG_APCC_ABBA_1	0.1944
p.P314Q	DO28923	OV	ICGC	VDMHDD	LIG_APCC_ABBA_1	0.1944
p.A330V	TCGA-19-5956	GBM	TCGA	VDMHDD	LIG_APCC_ABBA_1	0.1667
p.A330V	TCGA-AX-A0J1	UCEC	TCGA	VDMHDD	LIG_APCC_ABBA_1	0.1667
p.A330V	TCGA-B5-A3FC	UCEC	TCGA	VDMHDD	LIG_APCC_ABBA_1	0.1667
p.A330V	DO13863	GBM	ICGC	VDMHDD	LIG_APCC_ABBA_1	0.1667
p.A330V	DO41871	UCEC	ICGC	VDMHDD	LIG_APCC_ABBA_1	0.1667
p.A330V	DO41199	UCEC	ICGC	VDMHDD	LIG_APCC_ABBA_1	0.1667
p.R334W	TCGA-A5-A0G1	UCEC	TCGA	VDMHDD	LIG_APCC_ABBA_1	0.0556
p.R334W	TCGA-AG-A002	READ	TCGA	VDMHDD	LIG_APCC_ABBA_1	0.0556
p.R334W	TCGA-EO-A3B0	UCEC	TCGA	VDMHDD	LIG_APCC_ABBA_1	0.0556
p.R334W	TCGA-FI-A2D5	UCEC	TCGA	VDMHDD	LIG_APCC_ABBA_1	0.0556
p.R334W	DO219773	UCEC	ICGC	VDMHDD	LIG_APCC_ABBA_1	0.0556
p.R334W	DO42472	UCEC	ICGC	VDMHDD	LIG_APCC_ABBA_1	0.0556
p.R334W	DO41331	UCEC	ICGC	VDMHDD	LIG_APCC_ABBA_1	0.0556
p.R334W	SIDM01611	Endometrial Carcinoma	GDSC	VDMHDD	LIG_APCC_ABBA_1	0.0556
p.R334W	ACH-000996	Endometrial/Uterine Cancer	CCLE	VDMHDD	LIG_APCC_ABBA_1	0.0556
p.R334Q	TCGA-AX-A1CE	UCEC	TCGA	VDMHDD	LIG_APCC_ABBA_1	0.0556
p.R334Q	DO42280	UCEC	ICGC	VDMHDD	LIG_APCC_ABBA_1	0.0556
p.R334L	TCGA-EE-A184	SKCM	TCGA	VDMHDD	LIG_APCC_ABBA_1	0.0556
p.R334L	DO47442	SKCM	ICGC	VDMHDD	LIG_APCC_ABBA_1	0.0556
p.L312M	TCGA-EE-A2GT	SKCM	TCGA	VDMHDD	LIG_APCC_ABBA_1	0.1389
p.L312M	DO37946	SKCM	ICGC	VDMHDD	LIG_APCC_ABBA_1	0.1389
p.D323N	TCGA-EY-A1G8	UCEC	TCGA	VDMHDD	LIG_APCC_ABBA_1	0.5821
p.D323N	DO234339	ESAD	ICGC	VDMHDD	LIG_APCC_ABBA_1	0.5821
p.D323N	DO43578	UCEC	ICGC	VDMHDD	LIG_APCC_ABBA_1	0.5821
p.L326F	DO228974	LICA	ICGC	VDMHDD	LIG_APCC_ABBA_1	0.2778
p.T329M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VDMHDD	LIG_APCC_ABBA_1	0.1944
p.T329M	ACH-002256	Leukemia	CCLE	VDMHDD	LIG_APCC_ABBA_1	0.1944
p.T329M	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VDMHDD	LIG_APCC_ABBA_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VDMHDD

Degron related mutations and impact score

Drug responses associated with RBM48 mutations

All proteins holding degron of VDMHDD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5RL73	RNA-binding protein 48	LIG_APCC_ABBA_1	319:324	VDMHDD	APC,CDC20,FZR1	0.521	More...