DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VTETPPIT
Uniprot ID:
Q96HA1
Source protein:
Nuclear envelope pore membrane protein POM 121
Source gene:
POM121
Class:
DEG_SCF_FBW7_1
Location:
562:569
E3 ligase:
FBXW7
DEGRON score:
0.9827
ASA_SCORE:
96.3875
COIL:
0.9485
CONS_SCORE:
0.5547
DSS_SCORE:
0.5585
HELIX:
0.0175
FCONS_SCORE:
0.9035
RIG_SCORE:
0.6709
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A570V
DO52365
LUSC
ICGC
VTETPPIT
DEG_SCF_FBW7_1
0.3056
p.I575V
DO232681
PBCA
ICGC
VTETPPIT
DEG_SCF_FBW7_1
0.1667
Drug responses associated with POM121 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VTETPPIT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96HA1
Nuclear envelope pore membrane protein POM 121
DEG_SCF_FBW7_1
562:569
VTETPPIT
FBXW7
0.9827
More...
A6NF01
Putative nuclear envelope pore membrane protein POM 121B
DEG_SCF_FBW7_1
146:153
VTETPPIT
FBXW7
0.9873
More...